Crosstalk between autophagy and metabolic regulation of cancer stem cells

被引：78

作者：

El Hout, Mouradi ^{[1
,2
]}

Cosialls, Emma ^{[1
,2
]}

Mehrpour, Maryam ^{[1
,2
]}

Hamai, Ahmed ^{[1
,2
]}

机构：

[1] INSERM, U1151, INEM, CNRS,UMR 8253, F-75993 Paris, France

[2] Univ Paris 05, Sorbonne Paris Cite, F-75993 Paris, France

来源：

MOLECULAR CANCER | 2020年 / 19卷 / 01期

关键词：

Cancer stem cells; Autophagy; Metabolic heterogeneity; Lipid metabolism; Therapeutic target; BREAST-CANCER; OXIDATIVE-PHOSPHORYLATION; INITIATING CELLS; SELF-RENEWAL; TUMOR; GLUCOSE; RESISTANCE; INHIBITION; MAINTENANCE; SALINOMYCIN;

D O I：

10.1186/s12943-019-1126-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer is now considered as a heterogeneous ecosystem in which tumor cells collaborate with each other and with host cells in their microenvironment. As circumstances change, the ecosystem evolves to ensure the survival and growth of the cancer cells. In this ecosystem, metabolism is not only a key player but also drives stemness. In this review, we first summarize our current understanding of how autophagy influences cancer stem cell phenotype. We emphasize metabolic pathways in cancer stem cells and discuss how autophagy-mediated regulation metabolism is involved in their maintenance and proliferation. We then provide an update on the role of metabolic reprogramming and plasticity in cancer stem cells. Finally, we discuss how metabolic pathways in cancer stem cells could be therapeutically targeted.

引用

页数：17

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