Crosstalk between autophagy and metabolic regulation of cancer stem cells

被引：73
作者：
El Hout, Mouradi [1 ,2 ]
Cosialls, Emma [1 ,2 ]
Mehrpour, Maryam [1 ,2 ]
Hamai, Ahmed [1 ,2 ]
机构：
[1] INSERM, U1151, INEM, CNRS,UMR 8253, F-75993 Paris, France
[2] Univ Paris 05, Sorbonne Paris Cite, F-75993 Paris, France
来源：
MOLECULAR CANCER | 2020年 / 19卷 / 01期
关键词：
Cancer stem cells; Autophagy; Metabolic heterogeneity; Lipid metabolism; Therapeutic target; BREAST-CANCER; OXIDATIVE-PHOSPHORYLATION; INITIATING CELLS; SELF-RENEWAL; TUMOR; GLUCOSE; RESISTANCE; INHIBITION; MAINTENANCE; SALINOMYCIN;
D O I：
10.1186/s12943-019-1126-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer is now considered as a heterogeneous ecosystem in which tumor cells collaborate with each other and with host cells in their microenvironment. As circumstances change, the ecosystem evolves to ensure the survival and growth of the cancer cells. In this ecosystem, metabolism is not only a key player but also drives stemness. In this review, we first summarize our current understanding of how autophagy influences cancer stem cell phenotype. We emphasize metabolic pathways in cancer stem cells and discuss how autophagy-mediated regulation metabolism is involved in their maintenance and proliferation. We then provide an update on the role of metabolic reprogramming and plasticity in cancer stem cells. Finally, we discuss how metabolic pathways in cancer stem cells could be therapeutically targeted.
引用
收藏
页数：17
相关论文
共 126 条
  • [11] 188Re-Liposome Can Induce Mitochondrial Autophagy and Reverse Drug Resistance for Ovarian Cancer: From Bench Evidence to Preliminary Clinical Proof-of-Concept
    Chang, Chia-Ming
    Lan, Keng-Li
    Huang, Wen-Sheng
    Lee, Yi-Jang
    Lee, Te-Wei
    Chang, Chih-Hsien
    Chuang, Chi-Mu
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (05)
  • [12] ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells
    Chang, Ching-Wen
    Chen, Yu-Syuan
    Tsay, Yeou-Guang
    Han, Chia-Li
    Chen, Yu-Ju
    Yang, Cheng-Chieh
    Hung, Kai-Feng
    Lin, Chao-Hsiung
    Huang, Tsung-Yen
    Kao, Shou-Yen
    Lee, Te-Chang
    Lo, Jeng-Fan
    [J]. CELL DEATH & DISEASE, 2018, 9
  • [13] NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism
    Chen, Chia-Lin
    Kumar, Dinesh Babu Uthaya
    Punj, Vasu
    Xu, Jun
    Sher, Linda
    Tahara, Stanley M.
    Hess, Sonja
    Machida, Keigo
    [J]. CELL METABOLISM, 2016, 23 (01) : 206 - 219
  • [14] Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells
    Chen, Hsiuchen
    Chan, David C.
    [J]. CELL METABOLISM, 2017, 26 (01) : 39 - 48
  • [15] Chen KY, 2014, IEEE ENG MED BIO, P4759, DOI 10.1109/EMBC.2014.6944688
  • [16] Niclosamide: Beyond an antihelminthic drug
    Chen, Wei
    Mook, Robert A., Jr.
    Premont, Richard T.
    Wang, Jiangbo
    [J]. CELLULAR SIGNALLING, 2017, 41 : 89 - 96
  • [17] PARP-1 promotes autophagy via the AMPK/mTOR pathway in CNE-2 human nasopharyngeal carcinoma cells following ionizing radiation, while inhibition of autophagy contributes to the radiation sensitization of CNE-2 cells
    Chen, Ze-Tan
    Zhao, Wei
    Qu, Song
    Li, Ling
    Lu, Xiao-Di
    Su, Fang
    Liang, Zhong-Guo
    Guo, Si-Yan
    Zhu, Xiao-Dong
    [J]. MOLECULAR MEDICINE REPORTS, 2015, 12 (02) : 1868 - 1876
  • [18] Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment
    Ciavardelli, D.
    Rossi, C.
    Barcaroli, D.
    Volpe, S.
    Consalvo, A.
    Zucchelli, M.
    De Cola, A.
    Scavo, E.
    Carollo, R.
    D'Agostino, D.
    Forli, F.
    D'Aguanno, S.
    Todaro, M.
    Stassi, G.
    Di Ilio, C.
    De Laurenzi, V.
    Urbani, A.
    [J]. CELL DEATH & DISEASE, 2014, 5 : e1336 - e1336
  • [19] Even the Warburg effect can be oxidized Metabolic cooperation and tumor development
    Cordier-Bussat, Martine
    Thibert, Chantal
    Sujobert, Pierre
    Genestier, Laurent
    Fontaine, Eric
    Billaud, Marc
    [J]. M S-MEDECINE SCIENCES, 2018, 34 (8-9): : 701 - 708
  • [20] Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+breast cancer
    Corominas-Faja, Bruna
    Vellon, Luciano
    Cuyas, Elisabet
    Buxo, Maria
    Martin-Castillo, Begona
    Serra, Dolors
    Garcia, Jordi
    Menendez, Javier A.
    Lupu, Ruth
    [J]. HISTOLOGY AND HISTOPATHOLOGY, 2017, 32 (07) : 687 - 698
12345678910