Synthesis and in vitro antioxidant activity of new pyrimidin/benzothiazol-substituted piperazinyl flavones

被引:12
作者
Kladna, Aleksandra [1 ]
Berczynski, Pawel [2 ]
Duendar, Oya Bozdag [3 ]
UEnluesoy, Meltem Ceylan [3 ]
Sari, Elmas [3 ]
Bakinowska, Bernadetta [4 ]
Kruk, Irena [2 ]
Aboul-Enein, Hassan Y. [5 ]
机构
[1] Pomeranian Med Univ, Dept Hist Med & Med Eth, Rybacka 1, PL-70204 Szczecin, Poland
[2] West Pomeranian Univ Technol Szczecin, Inst Phys, Fac Mech Engn & Mechatron, Al Piastow 48-49, PL-70311 Szczecin, Poland
[3] Ankara Univ, Dept Pharmaceut Chem, Fac Pharm, TR-06100 Ankara, Turkey
[4] Pomeranian Oncol Ctr, Strzalowska 22, PL-70204 Szczecin, Poland
[5] Natl Res Ctr, Pharmaceut & Drug Ind Res Div, Pharmaceut & Med Chem Dept, Giza 12622, Egypt
关键词
antioxidant activity; chemiluminescence; free radical inhibitory activity; piperazinyl flavone analogs; spectroscopy; DNA-BINDING; SCAVENGING ACTIVITY; OXIDATIVE STRESS; GLUTAMIC-ACID; DERIVATIVES; SUPEROXIDE; CANCER; THALIDOMIDE; CHEMISTRY; CAPACITY;
D O I
10.4155/fmc-2018-0206
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Aim: Synthesis of novel 2(2-hydroxyphenyl) pyrimidine/benzothiazole piperazinyl-substituted flavones end evaluate their antioxidant activity. Results: Six novel 2-(2-hydroxyphenyl) pyrimidine/benzothiazole-substituted flavones were synthesized, their structures were confirmed by elementary and spectral analyses. The compounds were evaluated for their in vitro antioxidant potency by employing various antioxidant assays. Conclusion: All tested compounds acted as scavengers of free radicals like hydroxyl (15-45%),2,2-diphenyl-1-picrylhydrazyl(center dot) (17-48%) at 1.25 and 0.5mM concentrations respectively. The total antioxidant status activity values of the compounds ranged from 234.1 to 464.1m trolox equivalent/g, the total antioxidant capacity - from 24.9 to 52.7m trolox equivalent per gram. Compounds incorporating the benzothiazole group on the piperazine ring were more effective antioxidants than those with the 2-(2-hydroxyphenyl) pyrimidine group.
引用
收藏
页码:2293 / 2308
页数:16
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