Job Strain and the Risk of Stroke An Individual-Participant Data Meta-Analysis

被引：107

作者：

Fransson, Eleonor I. ^{[1
,2
,3
]}

Nyberg, Solja T. ^{[4
]}

Heikkila, Katriina ^{[4
]}

Alfredsson, Lars ^{[2
,5
]}

Bjorner, Jakob B. ^{[6
]}

Borritz, Marianne ^{[7
]}

Burr, Hermann ^{[8
]}

Dragano, Nico ^{[9
]}

Geuskens, Goedele A. ^{[10
]}

Goldberg, Marcel ^{[11
,12
]}

Hamer, Mark ^{[14
]}

Hooftman, Wendela E. ^{[10
]}

Houtman, Irene L. ^{[10
]}

Joensuu, Matti ^{[15
]}

Jokela, Markus ^{[16
]}

Knutsson, Anders ^{[18
]}

Koskenvuo, Markku ^{[17
]}

Koskinen, Aki ^{[15
]}

Kumari, Meena ^{[14
]}

Leineweber, Constanze ^{[3
]}

Lunau, Thorsten ^{[9
]}

Madsen, Ida E. H. ^{[6
]}

Hanson, Linda L. Magnusson ^{[3
]}

Nielsen, Martin L. ^{[7
]}

Nordin, Maria ^{[19
]}

Oksanen, Tuula ^{[20
]}

Pentti, Jaana ^{[20
]}

Pejtersen, Jan H. ^{[21
]}

Rugulies, Reiner ^{[6
,22
,23
]}

Salo, Paula ^{[20
,24
]}

Shipley, Martin J. ^{[14
]}

Steptoe, Andrew ^{[14
]}

Suominen, Sakari B. ^{[25
,26
,27
]}

Theorell, Toeres ^{[3
]}

Toppinen-Tanner, Salla ^{[15
]}

Vahtera, Jussi ^{[20
,26
,28
]}

Virtanen, Marianna ^{[15
]}

Vaananen, Ari ^{[15
]}

Westerholm, Peter J. M. ^{[29
]}

Westerlund, Hugo ^{[3
]}

Zins, Marie ^{[11
,12
]}

Britton, Annie ^{[14
]}

Brunner, Eric J. ^{[14
]}

Singh-Manoux, Archana ^{[13
,14
]}

Batty, G. David ^{[14
,30
,31
]}

Kivimaki, Mika ^{[14
,15
,16
]}

机构：

[1] Jonkoping Univ, Sch Hlth Sci, Dept Nat Sci & Biomed, SE-55111 Jonkoping, Sweden

[2] Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden

[3] Stockholm Univ, Stress Res Inst, S-10691 Stockholm, Sweden

[4] Finnish Inst Occupat Hlth, Tampere, Finland

[5] Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden

[6] Natl Res Ctr Working Environm, Copenhagen, Denmark

[7] Bispebjerg Hosp, Dept Occupat & Environm Med, Copenhagen, Denmark

[8] Fed Inst Occupat Safety & Hlth BAuA, Berlin, Germany

[9] Univ Dusseldorf, Inst Med Sociol, Fac Med, Dusseldorf, Germany

[10] Netherlands Org Appl Sci Res TNO, Hoofddorp, Netherlands

[11] Versailles St Quentin Univ, Versailles, France

[12] INSERM, Populat Based Epidemiol Cohorts Unit, UMS 011, F-94800 Villejuif, France

[13] INSERM, Ctr Res Epidemiol & Populat Hlth, U1018, Villejuif, France

[14] UCL, Dept Epidemiol & Publ Hlth, London, England

[15] Finnish Inst Occupat Hlth, Helsinki, Finland

[16] Univ Helsinki, Inst Behav Sci, Helsinki, Finland

[17] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland

[18] Mid Sweden Univ, Dept Hlth Sci, Sundsvall, Sweden

[19] Umea Univ, Dept Psychol, S-90187 Umea, Sweden

[20] Finnish Inst Occupat Hlth, Turku, Finland

[21] Danish Natl Ctr Social Res, Copenhagen, Denmark

[22] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark

[23] Univ Copenhagen, Dept Psychol, Copenhagen, Denmark

[24] Univ Turku, Dept Psychol, Turku, Finland

[25] Folkhalsan Res Ctr, Helsinki, Finland

[26] Univ Turku, Dept Publ Hlth, Turku, Finland

[27] Nord Sch Publ Hlth, Gothenburg, Sweden

[28] Turku Univ Hosp, FIN-20520 Turku, Finland

[29] Uppsala Univ, Dept Med Sci Occupat & Environm Med, Uppsala, Sweden

[30] Univ Edinburgh, Dept Psychol, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland

[31] Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh, Midlothian, Scotland

来源：

STROKE | 2015年 / 46卷 / 02期

基金：

英国医学研究理事会; 英国经济与社会研究理事会; 瑞典研究理事会; 芬兰科学院;

关键词：

psychological; stress; stroke; work; CORONARY-HEART-DISEASE; WOMEN; WORK; STRESS;

D O I：

10.1161/STROKEAHA.114.008019

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain. Methods-We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between job strain, a measure of work-related stress, and incident stroke. Results-In 1.8 million person-years at risk (mean follow-up 9.2 years), 2023 first-time stroke events were recorded. The age-and sex-adjusted hazard ratio for job strain relative to no job strain was 1.24 (95% confidence interval, 1.05; 1.47) for ischemic stroke, 1.01 (95% confidence interval, 0.75; 1.36) for hemorrhagic stroke, and 1.09 (95% confidence interval, 0.94; 1.26) for overall stroke. The association with ischemic stroke was robust to further adjustment for socioeconomic status. Conclusion-Job strain may be associated with an increased risk of ischemic stroke, but further research is needed to determine whether interventions targeting job strain would reduce stroke risk beyond existing preventive strategies.

引用

页码：557 / 559

页数：3

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