Peripheral Nerve Nanoimaging: Monitoring Treatment and Regeneration

被引:16
作者
Janjic, Jelena M. [1 ,2 ,3 ]
Gorantla, Vijay S. [4 ,5 ,6 ]
机构
[1] Duquesne Univ, Grad Sch Pharmaceut Sci, Sch Pharm, 600 Forbes Ave,415 Mellon Hall, Pittsburgh, PA 15282 USA
[2] Duquesne Univ, Chron Pain Res Consortium, 600 Forbes Ave, Pittsburgh, PA 15282 USA
[3] Univ Pittsburgh, McGowan Inst Regenerat Med, 1602 E Carson St, Pittsburgh, PA 15203 USA
[4] Wake Forest Inst Regenerat Med, Dept Surg, Wake Forest Baptist Med Ctr, 391 Technol Way, Winston Salem, NC 27101 USA
[5] Wake Forest Inst Regenerat Med, Dept Ophthalmol, Wake Forest Baptist Med Ctr, 391 Technol Way, Winston Salem, NC 27101 USA
[6] Wake Forest Inst Regenerat Med, Dept Bioengn, Wake Forest Baptist Med Ctr, 391 Technol Way, Winston Salem, NC 27101 USA
关键词
imaging; injury; nanomedicine; neuroinflammation; neuroregeneration; COMPOSITE TISSUE ALLOTRANSPLANTATION; TUMOR-ASSOCIATED MACROPHAGES; CELLS IN-VIVO; DRUG-DELIVERY; WALLERIAN DEGENERATION; EXPERIMENTAL STRATEGIES; SCHWANN-CELLS; F-19; MRI; T-CELLS; AXONAL REGENERATION;
D O I
10.1208/s12248-017-0129-x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Accidental and iatrogenic trauma are major causes of peripheral nerve injury. Healing after nerve injury is complex and often incomplete, which can lead to acute or chronic pain and functional impairment. Current assessment methods for nerve regeneration lack sensitivity and objectivity. There is a need for reliable and reproducible, noninvasive strategies with adequate spatial and temporal resolution for longitudinal evaluation of degeneration or regeneration after injury/treatment. Methods for noninvasive monitoring of the efficacy and effectiveness of neurotherapeutics in nerve regeneration or of neuropathic pain are needed to ensure adequacy and responsiveness to management, especially given the large variability in the patient populations, etiologies, and complexity of nerve injuries. Surrogate biomarkers are needed with positive predictive correlation for the dynamics and kinetics of neuroregeneration. They can provide direct real-time insight into the efficacy and mechanisms of individualized therapeutic intervention. Here, we review the state-of-the-art tools, technologies, and therapies in peripheral nerve injury and regeneration as well as provide perspectives for the future. We present compelling evidence that advancements in nanomedicine and innovation in nanotechnology such as nanotheranostics hold groundbreaking potential as paradigm shifts in noninvasive peripheral nerve imaging and drug delivery. Nanotechnology, which revolutionized molecular imaging in cancer and inflammatory disease, can be used to delineate dynamic molecular imaging signatures of neuroinflammation and neuroregeneration while simultaneously monitoring cellular or tissue response to drug therapy. We believe that current clinical successes of nanotechnology can and should be adopted and adapted to the science of peripheral nerve injury and regeneration.
引用
收藏
页码:1304 / 1316
页数:13
相关论文
共 135 条
[1]   Tracking immune cells in vivo using magnetic resonance imaging [J].
Ahrens, Eric T. ;
Bulte, Jeff W. M. .
NATURE REVIEWS IMMUNOLOGY, 2013, 13 (10) :755-763
[2]   Noninvasive Photoacoustic and Fluorescence Sentinel Lymph Node Identification using Dye-Loaded Perfluorocarbon Nanoparticles [J].
Akers, Walter J. ;
Kim, Chulhong ;
Berezin, Mikhail ;
Guo, Kevin ;
Fuhrhop, Ralph ;
Lanza, Gregory M. ;
Fischer, Georg M. ;
Daltrozzo, Ewald ;
Zumbusch, Andreas ;
Cai, Xin ;
Wang, Lihong V. ;
Achilefu, Samuel .
ACS NANO, 2011, 5 (01) :173-182
[3]  
Alfonso M I, 1998, Phys Med Rehabil Clin N Am, V9, P721
[4]   Priming events and retrograde injury signals - A new perspective on the cellular and molecular biology of nerve regeneration [J].
Ambron, RT ;
Walters, ET .
MOLECULAR NEUROBIOLOGY, 1996, 13 (01) :61-79
[5]   A novel probe for the non-invasive detection of tumor-associated inflammation [J].
Balducci, Anthony ;
Wen, Yi ;
Zhang, Yang ;
Helfer, Brooke M. ;
Hitchens, T. Kevin ;
Meng, Wilson S. ;
Wesa, Amy K. ;
Janjic, Jelena M. .
ONCOIMMUNOLOGY, 2013, 2 (02)
[6]   MR DIFFUSION TENSOR SPECTROSCOPY AND IMAGING [J].
BASSER, PJ ;
MATTIELLO, J ;
LEBIHAN, D .
BIOPHYSICAL JOURNAL, 1994, 66 (01) :259-267
[7]  
Basser PJ, 1996, J MAGN RESON SER B, V111, P209, DOI [10.1006/jmrb.1996.0086, 10.1016/j.jmr.2011.09.022]
[8]   Changes in water diffusion due to wallerian degeneration in peripheral nerve [J].
Beaulieu, C ;
Does, MD ;
Snyder, RE ;
Allen, PS .
MAGNETIC RESONANCE IN MEDICINE, 1996, 36 (04) :627-631
[9]   18F-FDG PET/MRI Can Be Used to Identify Injured Peripheral Nerves in a Model of Neuropathic Pain [J].
Behera, Deepak ;
Jacobs, Kathleen E. ;
Behera, Subrat ;
Rosenberg, Jarrett ;
Biswal, Sandip .
JOURNAL OF NUCLEAR MEDICINE, 2011, 52 (08) :1308-1312
[10]  
Benga A, 2017, INDIAN J PLAST SURG, V50, P5, DOI 10.4103/ijps.IJPS_14_17