A role of subicular and hippocampal afterdischarges in initiation of locomotor activity in rats

被引：14

作者：

Ma, JY

Brudzynski, SM

Leung, LWS

机构：

[1] Brock Univ, Dept Psychol, St Catharines, ON L2S 3A1, Canada

[2] Univ Western Ontario, Dept Physiol, London, ON N6A 5A5, Canada

[3] Univ Western Ontario, Dept Clin Neurol Sci, London, ON N6A 5A5, Canada

来源：

BRAIN RESEARCH | 1998年 / 793卷 / 1-2期

基金：

英国医学研究理事会; 加拿大自然科学与工程研究理事会;

关键词：

ventral subiculum; hippocampus; locomotor activity; afterdischarge; nucleus accumbens; N-methyl-D-aspartate; electrical stimulation;

D O I：

10.1016/S0006-8993(98)00165-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The possible role of a hippocampal afterdischarge (AD) episode in eliciting locomotor movements was evaluated in freely moving rats. Electrical stimulation of either the ventral subiculum (VSB) or the hippocampal CA1 region evoked an AD of 6-50 s in duration, which was followed by an increase in locomotor activity. Similar results were also observed after unilateral injection of N-methyl-D-aspartic acid (NMDA, 0.25 mu g or 1 mu g), a glutamate receptor agonist, into the VSB. Locomotor activity was not observed when either electrical or chemical stimulation of the VSB, or electrical stimulation of the CA1 region did not elicit an AD. In addition, the duration of the AD was positively correlated with the number of locomotor movements induced by stimulation of VSB or CA1 region. It is suggested that the hippocampal/subicular AD may be a necessary condition to induce locomotor activity by either chemical or electrical stimulation of the hippocampus in rats. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：112 / 118

页数：7

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