Enantioselective toxic effects of cyproconazole enantiomers against Rana nigromaculata

被引：24
作者：
Zhang, Wenjun [1 ,2 ]
Cheng, Cheng [1 ,2 ]
Chen, Li [1 ,2 ]
Deng, Yue [1 ,2 ]
Zhang, Luyao [1 ,2 ]
Li, Yao [3 ]
Qin, Yinan [2 ]
Diao, Jinling [2 ]
Zhou, Zhiqiang [1 ,2 ]
机构：
[1] Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Yuanmingyuan West Rd 2, Beijing 100193, Peoples R China
[2] China Agr Univ, Dept Appl Chem, Yuanmingyuan West Rd 2, Beijing 100193, Peoples R China
[3] Henan Agr Univ, Coll Resources & Environm, Wenhua Rd 95, Zhengzhou 450002, Henan, Peoples R China
来源：
ENVIRONMENTAL POLLUTION | 2018年 / 243卷
基金：
中国国家自然科学基金;
关键词：
Rana nigromaculata; Cyproconazole; Bioaccumulation; Enantioselective toxicity; Tissue distribution; AMPHIBIAN POPULATION DECLINES; TISSUE DISTRIBUTION; ENVIRONMENTAL FATE; DAPHNIA-MAGNA; FROGS; PESTICIDES; FUNGICIDES; EXPOSURE; CHINA; BIOACCUMULATION;
D O I：
10.1016/j.envpol.2018.09.060
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The environmental contaminant, especially pesticides, threatened the amphibian population. In this assay, the enantioselective behavior of cyproconazole on Rana nigromaculata was studied. We found LC50 (lethal concentration causing 50% mortality) of 4-enantiomers was nearly twice as 3-enantiomers in 96 h acute toxicity test. Besides, the significant considerable variation of oxidative stress and LDH (lactic dehydrogenase) induced by the four enantiomers indicated that cyproconazole could enantioselectively affect enzymes in tadpoles. Bioaccumulation experiments showed the order of cyproconazole in the tadpoles was 4-enantiomers>3- enantiomers>2- enantiomers>1- enantiomers during the exposure for 28d. In tissue distribution test, cyproconazole was formed and accumulated in order of 4-enantiomers>2-enantiomers>3- enantiomers>1- enantiomers, except that in the gut. During the elimination experiment, cyproconazole was rapidly eliminated by 95% within the only 24 h. These results suggested that the influence of enantioselective behavior should consider when assessing ecological risk of chiral pesticides to amphibians. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1825 / 1832
页数：8
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