Prognostic role of inflammatory biomarkers in metastatic breast cancer

Purpose: The effects of inflammation on the prognosis, life expectancy and several parameters such as response to treatment of breast cancer have been previously studied. The purpose of this study was to investigate the effect of inflammatory markers on prognosis in patients with metastatic breast cancer. Methods: This study was conducted on 81 patients with metastatic breast cancer who have been followed up at the Department of Medical Oncology, Hacettepe University Institute of Oncology, between December, 2009 and March, 2014. For all studied parameters Kaplan-Meier survival estimates and p values computed by log-rank test were calculated. A p value <0.05 was considered statistically significant. Results: Median follow-up time was 26 months. There were 38 deaths due to disease progression during the follow up. The levels of serum albumin, and erythrocyte sedimentation rate (ESR) were not associated with a significant effect on overall survival (OS). Among patients with a higher serum C-reactive protein (CRP), the estimated mean survival was 84 +/- 36 months, compared to 278 +/- 113 months among patients with a normal serum CRP (p=0.032). When patients with higher and normal lactate dehydrogenase (LDH) levels were compared, their 2-year OS survival rates were 68.2 and 87.7%, respectively (p =0.034). Among patients with higher serum ferritin levels, the estimated mean survival was 29 +/- 10 months, compared to 212 +/- 113 months for normal serum ferritin (p=0.01). Among patients with higher serum beta-2 microglobulin beta 2-m, the estimated mean OS survival was 28 +/- 8 months, compared to 84 +/- 57 months for those with normal levels (p<0.01). Conclusion: Serum CRP ferritin and)beta 2-M can be useful prognostic factors for OS in patients with metastatic breast cancer.