A One-Pot Synthesis of N-Aryl-2-Oxazolidinones and Cyclic Urethanes by the Lewis Base Catalyzed Fixation of Carbon Dioxide into Anilines and Bromoalkanes

被引：37

作者：

Niemi, Teemu ^{[1
]}

Perea-Buceta, Jesus E. ^{[1
]}

Fernandez, Israel ^{[2
]}

Hiltunen, Otto-Matti ^{[1
]}

Salo, Vili ^{[1
]}

Rautiainen, Sari ^{[1
]}

Raisanen, Minna T. ^{[1
]}

Repo, Timo ^{[1
]}

机构：

[1] Univ Helsinki, Dept Chem, POB 55, FIN-00014 Helsinki, Finland

[2] Univ Complutense Madrid, Fac Ciencias Quim, Dept Quim Organ 1, Ciudad Univ, E-28040 Madrid, Spain

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 30期

关键词：

2-oxazolidinones; antibiotics; carbon dioxide; density functional calculations; guanidine superbases; SELECTIVE SYNTHESIS; CHEMICAL FIXATION; CO2; CONVERSION; OXAZOLIDINONES; TRANSFORMATION; DBU;

D O I：

10.1002/chem.201602338

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The multicomponent assembly of pharmaceutically relevant N-aryl-oxazolidinones through the direct insertion of carbon dioxide into readily available anilines and dibromoalkanes is described. The addition of catalytic amounts of an organosuperbase such as Barton's base enables this transformation to proceed with high yields and exquisite substrate functional-group tolerance under ambient CO2 pressure and mild temperature. This report also provides the first proof-of-principle for the single-operation synthesis of elusive seven-membered ring cyclic urethanes.

引用

页码：10355 / 10359

页数：5

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