Association of HTRA1 polymorphism and bilaterality in advanced age-related macular degeneration

被引：35

作者：

Chen, Haoyu ^{[1
,2
,3
]}

Yang, Zhenglin ^{[2
,3
]}

Gibbs, Daniel ^{[2
,3
]}

Yang, Xian ^{[2
,3
]}

Hau, Vincent ^{[2
,3
]}

Zhao, Peiquan ^{[2
,3
,4
]}

Ma, Xiang ^{[2
,3
]}

Zeng, Jiexi ^{[2
,3
]}

Luo, Ling ^{[2
,3
]}

Pearson, Erik ^{[2
,3
]}

Constantine, Ryan ^{[2
,3
]}

Kaminoh, Yuuki ^{[2
,3
]}

Harmon, Jennifer ^{[2
,3
]}

Tong, Zongzhong ^{[2
,3
]}

Stratton, Charity A. ^{[2
,3
]}

Cameron, D. Joshua ^{[2
,3
]}

Tang, Shibo ^{[1
]}

Zhang, Kang ^{[2
,3
]}

机构：

[1] Sun Yat Sen Univ, State Key Lab Ophthalmol, Zhongshan Ophthalm Ctr, Guangzhou, Guangdong, Peoples R China

[2] Univ Utah, Dept Ophthalmol & Visual Sci, Moran Eye Ctr, Eccles Inst Human Genet, Salt Lake City, UT 84112 USA

[3] Univ Utah, Eccles Inst Human Genet, Program Human Mol Biol & Genet, Salt Lake City, UT 84112 USA

[4] Shanghai Jiao Tong Univ, Xinhua Hosp, Shanghai 200030, Peoples R China

来源：

VISION RESEARCH | 2008年 / 48卷 / 05期

关键词：

age-related macular degeneration; HTRA1; genetics; single nucleotide polymorphism;

D O I：

10.1016/j.visres.2007.10.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Single nucleotide polymorphism (SNP), rs11200638, in the promoter of HTRA1 has recently been shown to increase the risk for AMD. In order to investigate the association of this HTRA1 polymorphism and the bilaterality of AMD, we genotyped rs11200638 in control, unilateral, and bilateral advanced AMD patients. The A allele for SNP rs11200638 in HTRA1, was significantly more prevalent in bilateral wet AMD and GA patients than in unilateral groups (p = .02 and p = .03, respectively). The homozygote odds ratios of bilateral wet AMD and GA are significantly greater than those seen in unilateral groups (twofold and threefold increase, respectively). This finding is consistent with the role of HTRA1 in AMD pathogenesis and will help aid in the clinical management and prognosis of AMD patients. (C) 2008 Published by Elsevier Ltd.

引用

页码：690 / 694

页数：5

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