DETERMINATION OF THE METASTABLE ZONE WIDTH OF GLYCINE AQUEOUS SOLUTIONS FOR BATCH CRYSTALLIZATIONS

被引：23

作者：

Bonnin-Paris, Johanne ^{[1
]}

Bostyn, Stephane ^{[1
]}

Havet, Jean-Louis ^{[2
]}

Fauduet, Henri ^{[1
]}

机构：

[1] Univ Orleans, CNRS, ICOA, UMR 6005,Inst Univ Technol, F-45067 Orleans 2, France

[2] Lab Genie Procedes Environm Energie & Sante EA 21, Paris, France

来源：

CHEMICAL ENGINEERING COMMUNICATIONS | 2011年 / 198卷 / 08期

关键词：

Crystallization; Experimental design; Glycine; Metastable zone width; CRYSTAL-GROWTH; NUCLEATION; KINETICS; SOLUBILITY; SODIUM; SPECTROSCOPY; PARACETAMOL; POTASSIUM; SULFATE; PHASE;

D O I：

10.1080/00986445.2011.545301

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The aim of this study was to determine the metastable zone width of aqueous solutions of glycine for non-seeded batch crystallizations. The saturation curve was determined by studying the heating rate influence on the apparent saturation temperatures of several solutions. A linear regression was then applied to obtain the saturation temperatures. The spontaneous nucleation curve was obtained by measuring the crystallization temperatures of several solutions at different cooling rates. The results show that the apparent nucleation order of the glycine aqueous solutions was around 3.5 +/- 0.5. Moreover, from the experimental data, a second-order polynomial model was established by using the experimental design method. This model enables the expression of crystallization temperature to be defined as a function of concentration and cooling rate. The results show that the model fits well (R20.99; Q20.98) and that the cooling rate is the most influential parameter.

引用

页码：1004 / 1017

页数：14

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