Brief Report: Maternal Opioid Prescription from Preconception Through Pregnancy and the Odds of Autism Spectrum Disorder and Autism Features in Children

被引：26

作者：

Rubenstein, Eric ^{[1
]}

Young, Jessica C. ^{[2
]}

Croen, Lisa A. ^{[3
]}

DiGuiseppi, Carolyn ^{[4
]}

Dowling, Nicole F. ^{[5
]}

Lee, Li-Ching ^{[6
]}

Schieve, Laura ^{[5
]}

Wiggins, Lisa D. ^{[5
]}

Daniels, Julie ^{[2
]}

机构：

[1] Univ Wisconsin, Waisman Ctr, Rm 529,1500 Highland Ave, Madison, WI 53705 USA

[2] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, 135 Dauer Dr, Chapel Hill, NC 27599 USA

[3] Kaiser Permanente, Div Res, 2000 Broadway, Oakland, CA 94612 USA

[4] Univ Colorado, Sch Publ Hlth, Colorado Sch Publ Hlth, Dept Epidemiol, Anschutz Med Campus,13001 E 17th Pl, Aurora, CO 80045 USA

[5] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd, Atlanta, GA 30329 USA

[6] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, 615 N Wolfe St, Baltimore, MD 21205 USA

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2019年 / 49卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Risk factor; Opioid; ASD; Developmental disorder; Pregnancy; EARLY DEVELOPMENT SEED; BUPRENORPHINE; EPIDEMIOLOGY; EXPOSURE; CENTERS; MOTHERS; BIRTH; BORN;

D O I：

10.1007/s10803-018-3721-8

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Opioid use during pregnancy is associated with suboptimal pregnancy outcomes. Little is known about child neurodevelopmental outcomes. We examined associations between maternal opioid prescriptions preconception to delivery (peri-pregnancy) and child's risk of ASD, developmental delay/disorder (DD) with no ASD features, or ASD/DD with autism features in the Study to Explore Early Development, a case-control study of neurodevelopment. Preconception opioid prescription was associated with 2.43 times the odds of ASD [95% confidence interval (CI) 0.99, 6.02] and 2.64 times the odds of ASD/DD with autism features (95% CI 1.10, 6.31) compared to mothers without prescriptions. Odds for ASD and ASD/DD were non-significantly elevated for first trimester prescriptions. Work exploring mechanisms and timing between peri-pregnancy opioid use and child neurodevelopment is needed.

引用

页码：376 / 382

页数：7

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