One-pot organocatalytic/multicomponent approach for the preparation of novel enantioenriched non-natural selenium-based peptoids and peptide-peptoid conjugates

被引：11

作者：

de la Torre, Alexander F. ^{[1
,4
]}

Ali, Akbar ^{[2
]}

Galetto, Fabio Z. ^{[3
]}

Braga, Antonio L. ^{[3
]}

Delgado, Jose A. C. ^{[4
]}

Paixao, Marcio W. ^{[4
]}

机构：

[1] Univ Concepcion, Fac Ciencias Quim, Dept Quim Organ, Edmundo Larenas 234 Interior Casilla 160-C, Concepcion, Chile

[2] Univ Sargodha, Dept Chem, Sargodha 40100, Pakistan

[3] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC, Brazil

[4] Fed Univ Sao Carlos UFSCar, Ctr Excellence Res Sustainable Chem CERSusChem, Dept Chem, Rodovia Washington Luis,Km 235 SP 310, BR-13565905 Sao Carlos, SP, Brazil

来源：

MOLECULAR DIVERSITY | 2020年 / 24卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

Organocatalysis; Multicomponent reactions; Ugi reaction; Peptoids; Selenocysteine; MULTICOMPONENT REACTIONS; SELENOCYSTEINE DERIVATIVES; STEREOSELECTIVE-SYNTHESIS; AMINO-ACID; C-C; DISELENIDE; CHEMISTRY; OXIDATION; CATALYSTS; GPX;

D O I：

10.1007/s11030-019-09923-w

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A combined organocatalytic and multicomponent synthetic approach was designed for the preparation of selenium-based peptoids and peptide-peptoid conjugates. This single-step synthetic protocol comprises the organocatalytic asymmetric insertion of phenylselenium in the aldehyde moiety followed by the Ugi four-component reaction which results in obtaining the desired compounds in good-to-moderate yields and with good-to-excellent levels of stereoselectivity. [GRAPHICS] .

引用

页码：1 / 10

页数：10

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