New Type III CRISPR variant and programmable RNA targeting tool: Oh, thank heaven for Cas7-11

被引：12

作者：

Catchpole, Ryan J. ^{[1
]}

Terns, Michael P. ^{[1
,2
,3
]}

机构：

[1] Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA

[2] Univ Georgia, Dept Genet, Athens, GA 30602 USA

[3] Univ Georgia, Dept Microbiol, Athens, GA 30602 USA

来源：

MOLECULAR CELL | 2021年 / 81卷 / 21期

关键词：

D O I：

10.1016/j.molcel.2021.10.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

center dot O zcan et al. (2021) and van Beljouw et al. (2021) characterize a novel Type III-E CRISPR-Cas subtype, composed of a single polypeptide with crRNA processing and sequence-specific RNA cleavage activities, that provides a new RNA knockdown tool for mammalian cells with fewer off-target effects than current technologies.

引用

页码：4354 / 4356

页数：3

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