Copy-number polymorphisms:: mining the tip of an iceberg

被引：33

作者：

Buckley, PG ^{[1
]}

Mantripragada, KK ^{[1
]}

Piotrowski, A ^{[1
]}

de Ståhl, TD ^{[1
]}

Dumanski, JP ^{[1
]}

机构：

[1] Univ Uppsala, Rudbeck Lab, Dept Genet & Pathol, S-75185 Uppsala, Sweden

来源：

TRENDS IN GENETICS | 2005年 / 21卷 / 06期

关键词：

D O I：

10.1016/j.tig.2005.04.007

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Copy-number polymorphisms (CNPs) represent a greatly underestimated aspect of human genetic variation. Recently, two landmark studies reported genome-wide analyses of CNPs in normal individuals and represent the beginning of an understanding of this type of large-scale variation. Future array-CGH-based CNP analyses should include standard criteria on a common microarray platform. It is only when parallel analyses of CNPs and SNPs are performed in an integrated format that we will obtain a global picture of our genetic diversity.

引用

页码：315 / 317

页数：3

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