Placental Pathologic Changes Associated with Fetal Growth Restriction and Consequent Neonatal Outcomes

被引：6

作者：

Hwa Im, Do ^{[1
]}

Kim, Young Nam ^{[1
,2
]}

Cho, Hwa Jin ^{[3
]}

Park, Yong Hee ^{[1
]}

Kim, Da Hyun ^{[1
]}

Byun, Jung Mi ^{[1
,2
]}

Jeong, Dae Hoon ^{[1
,2
]}

Lee, Kyung Bok ^{[1
,2
]}

Sung, Moon Su ^{[1
]}

机构：

[1] Inje Univ, Busan Paik Hosp, Dept Obstet & Gynecol, Busan, South Korea

[2] Paik Inje Mem Inst Clin Med Res, Pusan, South Korea

[3] Inje Univ, Busan Paik Hosp, Dept Pathol, Pusan, South Korea

来源：

FETAL AND PEDIATRIC PATHOLOGY | 2021年 / 40卷 / 05期

关键词：

Fetal growth restriction(FGR); placental dysfunction; pathologic findings; THROMBOTIC VASCULOPATHY; GESTATIONAL-AGE; BIRTH-WEIGHT; PREGNANCIES; LESIONS;

D O I：

10.1080/15513815.2020.1723147

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objective: To evaluate the pathological changes of the placenta to determine the mechanism underlying placenta-derived fetal growth restriction (FGR) and investigate its influence on neonatal outcomes. Study design: This retrospective case-control study included 120 singleton pregnancies with FGR as well as 120 gestational age-matched controls. We compared the placental pathological findings and neonatal outcomes according to the presence of placental malperfusion. Results: The FGR group demonstrated lower placental weight (350.8 +/- 118.8 vs. 436.1 +/- 109.7g, P < .0001), smaller chorionic plate area (157.7 +/- 48.0 vs. 201.5 +/- 53.4 cm(2), P < .0001), and higher rate of villous change lesions (84.2% vs. 52.5%, P < .0001) than the control group. FGR neonates with placental malperfusion had a higher rate of adverse neonatal outcomes (87.1% vs. 63.2%, P = .0175). Conclusion: Small placentas and placental malperfusion reflected in villous changes are associated with FGR. FGR neonates with placental malperfusion are more susceptible to adverse neonatal outcomes.

引用

页码：430 / 441

页数：12

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