Placental Pathologic Changes Associated with Fetal Growth Restriction and Consequent Neonatal Outcomes

被引：6
|
作者：
Hwa Im, Do [1 ]
Kim, Young Nam [1 ,2 ]
Cho, Hwa Jin [3 ]
Park, Yong Hee [1 ]
Kim, Da Hyun [1 ]
Byun, Jung Mi [1 ,2 ]
Jeong, Dae Hoon [1 ,2 ]
Lee, Kyung Bok [1 ,2 ]
Sung, Moon Su [1 ]
机构：
[1] Inje Univ, Busan Paik Hosp, Dept Obstet & Gynecol, Busan, South Korea
[2] Paik Inje Mem Inst Clin Med Res, Pusan, South Korea
[3] Inje Univ, Busan Paik Hosp, Dept Pathol, Pusan, South Korea
来源：
FETAL AND PEDIATRIC PATHOLOGY | 2021年 / 40卷 / 05期
关键词：
Fetal growth restriction(FGR); placental dysfunction; pathologic findings; THROMBOTIC VASCULOPATHY; GESTATIONAL-AGE; BIRTH-WEIGHT; PREGNANCIES; LESIONS;
D O I：
10.1080/15513815.2020.1723147
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Objective: To evaluate the pathological changes of the placenta to determine the mechanism underlying placenta-derived fetal growth restriction (FGR) and investigate its influence on neonatal outcomes. Study design: This retrospective case-control study included 120 singleton pregnancies with FGR as well as 120 gestational age-matched controls. We compared the placental pathological findings and neonatal outcomes according to the presence of placental malperfusion. Results: The FGR group demonstrated lower placental weight (350.8 +/- 118.8 vs. 436.1 +/- 109.7g, P < .0001), smaller chorionic plate area (157.7 +/- 48.0 vs. 201.5 +/- 53.4 cm(2), P < .0001), and higher rate of villous change lesions (84.2% vs. 52.5%, P < .0001) than the control group. FGR neonates with placental malperfusion had a higher rate of adverse neonatal outcomes (87.1% vs. 63.2%, P = .0175). Conclusion: Small placentas and placental malperfusion reflected in villous changes are associated with FGR. FGR neonates with placental malperfusion are more susceptible to adverse neonatal outcomes.
引用
收藏
页码：430 / 441
页数：12
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