Optical coherence tomography in papilledema and pseudopapilledema with and without optic nerve head drusen

被引:56
作者
Bassi, Shikha Talwar [1 ]
Mohana, Kuppuswamy Parthasarthy [1 ]
机构
[1] Sankara Nethralaya, Dept Neuro Ophthalmol, Madras 600006, Tamil Nadu, India
关键词
Optic nerve head drusen; optical coherence tomography; papilledema; pseudopapilloedema; MILD PAPILLEDEMA; FIBER LAYER; DISC EDEMA; DOMAIN; OCT;
D O I
10.4103/0301-4738.149136
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Aim: To compare the spectral domain optical coherence tomography (SD-OCT) findings of the optic disc and the peripapillary retina of patients with a true papilledema and pseudopapilledema with and without optic nerve head drusen (ONHD). Study Design: Retrospective Case Control Study. Subjects and Methods: Peripapillary retinal nerve fiber layer (PPRNFL) thickness as depicted by SD-OCT of 94 eyes of 66 patients with papilledema (30 eyes), pseudopapiledema (31 eyes), and normal controls (33 eyes) was analyzed. The mean RNFL thickness, total retinal thickness (TRT) at a superior and inferior edge of the disc and the quadrant wise topography of increased RNFL were compared in all three groups. Sensitivity, specificity, and area under the receiver operating characteristic curve (AROC) were calculated for all the parameters. Results: The median RNFL thickness was 185.4 (129.5-349.3 mu m), 122.3 (109-156.3 mu m) and 91.62 +/- 7 mu m in papilledema, pseudopapilledema, and controls, respectively. Papilledema group had thicker PPRNFL in all quadrants except temporal quadrant. TRT was thicker in papilledema and pseudopapilledema compared to controls. ONHD could be directly visualized as high reflective clumps in the sub-retinal space or the RNFL in 30 eyes. Increased RNFL thickness in all four quadrants was noted 43.3% in papilledema and 9.7% in pseudopapilledema. Normal RNFL thickness in all four quadrants was noted in 0% in papilledema and 32.3% in pseudopapilledema. Nasal RNFL had the highest AROC (0.792) indicating high diagnostic ability to differentiate papilledema from pseudopapilledema. Conclusion: SD-OCT can be used as a tool to differentiate between papilledema and pseudopapilledema.
引用
收藏
页码:1146 / 1151
页数:6
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