Prognostic significance of MSI2 predicts unfavorable outcome in adult B-acute lymphoblastic leukemia

被引：28
作者：
Aly, R. M. [1 ]
Ghazy, H. F. [2 ]
机构：
[1] Mansoura Univ, Fac Med, Dept Clin Pathol, Mansoura 12345, Egypt
[2] Mansoura Univ, Fac Med, Dept Internal Med, Med Oncol Unit, Mansoura 12345, Egypt
来源：
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY | 2015年 / 37卷 / 02期
关键词：
Prognosis; MSI2; acute lymphoblastic leukemia; adult; BCR-ABL1; negative; RNA-BINDING PROTEIN; ACUTE MYELOID-LEUKEMIA; GENE-EXPRESSION; STEM-CELL; MAMMALIAN CNS; PRECURSOR; PROGRESSION; MUSASHI1; MULTICENTER; PHENOTYPE;
D O I：
10.1111/ijlh.12284
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
IntroductionThe Musashi-2 gene (MSI2) is implicated in leukemogenesis, and high MSI2 expression has been associated with decreased survival in acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), suggesting its use as a new prognostic marker. We aimed to validate the prognostic significance of MSI2 in ALL. MethodsMSI2 expression was measured by real-time polymerase chain reaction in 140 adult B-ALL patients and compared to controls. ResultsMSI2 expression level in patients was significantly higher when compared to the control group (P=0.001). High MSI2 expression did not correlate with the clinical characteristics of patients. However, patients with high MSI2 expression had significantly lower incidence of complete remission (CR) (P=0.03), inferior overall survival (P=0.018), and shorter disease-free survival (P=0.001). Multivariate analysis revealed that high MSI2 expression was an independent prognostic factor for adult BCR-ABL1-negative B-ALL patients. ConclusionThese results confirm the association of MSI2 expression with outcome in adult B-ALL and demonstrate the utility of MSI2 as a clinical prognostic biomarker.
引用
收藏
页码：272 / 278
页数：7
相关论文
共 43 条
[1]   Gene expression profiling for diagnosis and therapy in acute leukaemia and other haematologic malignancies [J].
Bacher, Ulrike ;
Kohlmann, Alexander ;
Haferlach, Torsten .
CANCER TREATMENT REVIEWS, 2010, 36 (08) :637-646
[2]  
Barbouti A, 2003, CANCER RES, V63, P1202
[3]  
Bassan Renato, 2005, Haematologica, V90, P1299
[4]   The frequency of NPM1 mutations in childhood acute myeloid leukemia [J].
Braoudaki, Maria ;
Papathanassiou, Chrissa ;
Katsibardi, Katerina ;
Tourkadoni, Natalia ;
Karamolegou, Kalliopi ;
Tzortzatou-Stathopoulou, Fotini .
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2010, 3
[5]   Protein expression of a triad of frequently methylated genes, p73, p57Kip2, and p15, has prognostic value in adult acute lymphocytic leukemia independently of its methylation status [J].
Bueso-Ramos, C ;
Xu, YL ;
McDonnell, TJ ;
Brisbay, S ;
Pierce, S ;
Kantarjian, H ;
Rosner, G ;
Garcia-Manero, G .
JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (17) :3932-3939
[6]   Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia [J].
Bullinger, L ;
Döhner, K ;
Bair, E ;
Fröhling, S ;
Schlenk, RF ;
Tibshirani, R ;
Döhner, H ;
Pollack, JR .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (16) :1605-1616
[7]   Patients' age and BCR-ABL frequency in adult B-precursor ALL:: a retrospective analysis from the GMALL study group [J].
Burmeister, Thomas ;
Schwartz, Stefan ;
Bartram, Claus R. ;
Goekbuget, Nicola ;
Hoelzer, Dieter ;
Thiel, Eckhard .
BLOOD, 2008, 112 (03) :918-919
[8]   MSI2 protein expression predicts unfavorable outcome in acute myeloid leukemia [J].
Byers, Richard J. ;
Currie, Treeve ;
Tholouli, Eleni ;
Rodig, Scott J. ;
Kutok, Jeffery L. .
BLOOD, 2011, 118 (10) :2857-2867
[9]   Treatment of Adult Acute Lymphoblastic Leukemia [J].
Goekbuget, Nicola ;
Hoelzer, Dieter .
SEMINARS IN HEMATOLOGY, 2009, 46 (01) :64-75
[10]   An RNAi Screen Identifies Msi2 and Prox1 as Having Opposite Roles in the Regulation of Hematopoietic Stem Cell Activity [J].
Hope, Kristin J. ;
Cellot, Sonia ;
Ting, Stephen B. ;
MacRae, Tara ;
Mayotte, Nadine ;
Iscove, Norman N. ;
Sauvageau, Guy .
CELL STEM CELL, 2010, 7 (01) :101-113
12345