High-dose chemotherapy and autologous stem-cell transplantation without consolidating radiotherapy as first-line treatment for primary lymphoma of the central nervous system

被引：147

作者：

Illerhaus, Gerald ^{[1
]}

Mueller, Fabian ^{[1
]}

Feuerhake, Friedrich ^{[2
]}

Schafer, Arnd-Oliver ^{[3
]}

Ostertag, Christoph ^{[4
]}

Finke, Juergen ^{[1
]}

机构：

[1] Univ Med Ctr Freiburg, Dept Haematol & Oncol, Hugstetter Str 55, D-79106 Freiburg, Germany

[2] Univ Med Ctr Freiburg, Dept Neuropathol, Freiburg, Germany

[3] Univ Med Ctr Freiburg, Dept Radiol, Freiburg, Germany

[4] Univ Med Ctr Freiburg, Dept Stereotact Neurosurg, Freiburg, Germany

来源：

HAEMATOLOGICA | 2007年 / 93卷 / 01期

关键词：

PCNSL; high-dose chemotherapy; stem-cell transplantation; whole-brain-radiotherapy; neurotoxicity;

D O I：

10.3324/haematol.11771

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thirteen patients (age 38-67 years) with primary lymphoma of the central nervous system (CNS) were treated with methotrexate and cytarabine/thiotepa induction-chemotherapy followed by high-dose carmustine/thiotepa and autologous stem-cell transplantation. Radiotherapy was restricted to patients who did not respond completely to chemotherapy. With a median follow up of 25 months, 3-year DFS and OS was 77%.

引用

页码：147 / 148

页数：2

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