Voriconazole-induced QT interval prolongation and ventricular tachycardia: A non-concentration-dependent adverse effect

被引：50
作者：
Alkan, Y
Haefeli, WE
Burhenne, J
Stein, J
Yaniv, I
Shalit, I
机构：
[1] Tel Aviv Univ, Sackler Sch Med, Schneider Childrens Med Ctr Israel, Infect Dis Unit, IL-69978 Tel Aviv, Israel
[2] Tel Aviv Univ, Sackler Sch Med, Schneider Childrens Med Ctr Israel, Dept Pediat Hematol Oncol, IL-69978 Tel Aviv, Israel
[3] Univ Heidelberg, Dept Internal Med 6, Heidelberg, Germany
来源：
CLINICAL INFECTIOUS DISEASES | 2004年 / 39卷 / 06期
关键词：
D O I：
10.1086/423275
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A 15-year-old patient with acute lymphoblastic leukemia and Fusarium infection was treated with voriconazole. She developed asymptomatic bradycardia, QT interval prolongation, and nonsustained, polymorphic ventricular tachycardia, which recurred upon rechallenge with the drug. Voriconazole levels and metabolism were within expected normal values. This non-concentration-dependent, voriconazole-associated ventricular tachycardia mandates cardiac rhythm monitoring during voriconazole treatment.
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收藏
页码：E49 / E52
页数：4
相关论文
共 12 条
  • [1] Bazett HC, 1920, HEART-J STUD CIRC, V7, P353
  • [2] Effects of fluoroquinolones on HERG currents
    Bischoff, U
    Schmidt, C
    Netzer, R
    Pongs, O
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 406 (03) : 341 - 343
  • [3] De Ponti F, 2002, DRUG SAFETY, V25, P263
  • [4] Dumaine R, 1998, J PHARMACOL EXP THER, V286, P727
  • [5] Probable case of Torsades de Pointes induced by fluconazole
    Khazan, M
    Mathis, AS
    [J]. PHARMACOTHERAPY, 2002, 22 (12): : 1632 - 1637
  • [6] A METHOD FOR ESTIMATING THE PROBABILITY OF ADVERSE DRUG-REACTIONS
    NARANJO, CA
    BUSTO, U
    SELLERS, EM
    SANDOR, P
    RUIZ, I
    ROBERTS, EA
    JANECEK, E
    DOMECQ, C
    GREENBLATT, DJ
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1981, 30 (02) : 239 - 245
  • [7] VENTRICULAR-FIBRILLATION SECONDARY TO ITRACONAZOLE INDUCED HYPOKALEMIA
    NELSON, MR
    SMITH, D
    ERSKINE, D
    GAZZARD, BG
    [J]. JOURNAL OF INFECTION, 1993, 26 (03) : 348 - 348
  • [8] PASERCHIA LA, 1994, CLIN PHARMACOL THER, V55, P146
  • [9] Development and validation of a high-performance liquid chromatography assay for voriconazole
    Pennick, GJ
    Clark, M
    Sutton, DA
    Rinaldi, MG
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (07) : 2348 - 2350
  • [10] *PFIZ PHARM ISR, 2002, VFEND VOR PACK INS
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