INCREASING THE SOLUBILITY OF PHENAZEPAM BY FORMING SOLID DISPERSIONS

被引：1

作者：

Krasnyuk, I. I., Jr. ^{[1
]}

Manakhova, O. V. ^{[1
]}

Khabriev, R. U. ^{[1
]}

Popkov, V. A. ^{[1
]}

Reshetnyak, V. Yu. ^{[1
]}

Krasnyuk, O. I. ^{[1
]}

机构：

[1] Sechenov Moscow Med Acad, Moscow, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2010年 / 44卷 / 05期

关键词：

solid dispersion; solubility; phenazepam; poly(ethyleneglycol)-1500; poly(vinylpyrrolidone)10000; beta-cyclodextrin;

D O I：

10.1007/s11094-010-0448-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effect of solid dispersion (SD) formation on the solubility of phenazepam has been studied. Phenazepam and its SDs with poly(ethyleneglycol)-1500 (PEG), poly(vinylpyrrolidone)-10000 (PVP), and beta-cyclodextrin were studied. The SD with PVP increases both the solubility and the dissolution rate of phenazepam. Results obtained by a complex of physical and chemical methods suggest that the improved release of phenazepam from the SD with PVP is due to solubilization, amorphization, and formation of a colloidal dispersion of the parent drug substance.

引用

页码：274 / 277

页数：4