HLA-DPB1 alleles association of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus

被引：23

作者：

Sebastiani, GD

Galeazzi, M

Tincani, A

Scorza, R

Mathieu, A

Passiu, G

Morozzi, G

Piette, JC

Cervera, R

Houssiau, F

Smolen, J

Nebro, AF

De Ramon, E

Goral, AJ

Papasteriades, C

Ferrara, GB

Carcassi, C

Bellisai, F

Marcolongo, R

机构：

[1] Azienda Opsed San Camillo Forlanini, UO Complessa Reumatol, Rome, Italy

[2] Univ Siena, Ist Reumatol, I-53100 Siena, Italy

[3] Spedali Civil Brescia, Serv Immunol Clin, I-25125 Brescia, Italy

[4] Univ Milan, Ist Med Interna Malattie Infett & Immunopatol, Milan, Italy

[5] Univ Cagliari, Cattedra Reumatol 2, Cagliari, Italy

[6] CHU Pitie Salpetriere, Serv Med Interne, Paris, France

[7] Hosp Clin Barcelona, Unitat Malalties Autoimmunes Sistem, Barcelona, Spain

[8] Catholic Univ Louvain, Serv Rhumatol, Brussels, Belgium

[9] Lainz Hosp, Dept Med, A-1130 Vienna, Austria

[10] Hosp & Univ Malaga, Malaga, Spain

[11] Inst Rheumatol, Warsaw, Poland

[12] Evangelismos Med Ctr, Athens, Greece

[13] Ctr Biotechnol Avanzate, Genoa, Italy

[14] Univ Cagliari, Dipartimento Genet Med, Cagliari, Italy

来源：

LUPUS | 2003年 / 12卷 / 07期

关键词：

anti-beta 2GPI antibodies; anticardiolipin antibodies; antiphospholipid syndrome; HLA; HLA-DPB1; locus; systemic lupus erythematosus;

D O I：

10.1191/0961203303lu402oa

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Our objective was to determine the HLA-DPB1 allele associations of anticardiolipin (aCL) and anti-beta(2)GPI (abeta(2)GPI) antibodies, and of clinical manifestations of the antiphospholipid syndrome (APS), in systemic lupus erythematosus (SLE). We studied 577 European patients with SLE. aCL and ab2GPI antibodies were measured by ELISA. Molecular typing of HLA-DPB1 locus was performed by polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) method. aCL showed positive association with -DPB1 *1501 (P = 0.005, OR = 7.4), and -DPB1 *2301 (P = 0.009, OR = 3.3). abeta(2)GPI showed positive association with -DPB1 *0301 (P = 0.01, OR 1.9), and -DPB1 *1901 (P 0.004, OR 8.1). In addition, livedo reticularis was associated with -DPB1 *1401, and Raynaud's phenomenon with -DPB1 *2001. In conclusion, HLA-DPB1 locus may contribute to the genetic predisposition to develop antiphospholipid antibodies and clinical manifestations of the APS in patients with SLE.

引用

页码：560 / 563

页数：4

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