Operating procedures for electrochemotherapy in bone metastases: Results from a multicenter prospective study on 102 patients

被引：21

作者：

Campanacci, Laura ^{[1
]}

Bianchi, Giuseppe ^{[1
]}

Cevolani, Luca ^{[1
]}

Errani, Costantino ^{[1
]}

Ciani, Giovanni ^{[1
]}

Facchini, Giancarlo ^{[2
]}

Spinnato, Paolo ^{[2
]}

Tognu, Andrea ^{[3
]}

Massari, Leo ^{[4
]}

Cornelis, Francois H. ^{[5
]}

Mosconi, Mario ^{[6
]}

Screpis, Daniele ^{[7
]}

Benazzo, Francesco ^{[8
]}

Rossi, Barbara ^{[9
]}

Bonicoli, Enrico ^{[10
]}

Fazioli, Flavio ^{[11
]}

Nicolosi, Mario ^{[12
]}

Boffano, Michele ^{[13
]}

Piana, Raimondo ^{[13
]}

De Terlizzi, Francesca ^{[14
]}

Cadossi, Matteo ^{[14
]}

Donati, Davide Maria ^{[1
]}

机构：

[1] IRCCS Ist Ortoped Rizzoli, Orthopaed & Traumatol Clin Prevalently Oncol 3, Via Pupilli 1, I-40136 Bologna, Italy

[2] IRCCS Ist Ortoped Rizzoli, Dept Radiol, Via Pupilli 1, I-40136 Bologna, Italy

[3] IRCCS Ist Ortoped Rizzoli, Dept Anaestesiol, Via Pupilli 1, I-40136 Bologna, Italy

[4] Univ Ferrara, Azienda Osped Univ S Anna Ferrara, UO Clin Ortoped & Traumatol, Dipartimento Neurosci & Riabilitaz, Ferrara, Italy

[5] Sorbonne Univ, Dept Intervent Radiol, Hop Tenon 4 Rue Chine, F-75020 Paris, France

[6] Fdn IRCCS Policlin San Matteo Pavia, UOC Ortopedia & Traumatol, Pavia, Italy

[7] Osped Sacrocuore Don Calabria, UO Ortopedia & Traumatol, Via A Sempreboni 5, I-37024 Negrar Di Valpolicella, Vr, Italy

[8] Sez Univ Chirurg Protes Ad Indirizzo Robot, Unita Traumatol, Sport Fdn Poliambulanza Ist Osped, Brescia, Italy

[9] IRCCS Regina Elena Natl Canc Inst, UOC Oncol Orthopaed, Rome, Italy

[10] UO Ortopedia & Traumatol 1a Univ, Cisanello Pisa, Italy

[11] Natl Canc Inst G Pascale, Div Oncol Orthoped, Naples, Italy

[12] Ist Clin Homanitas, Catania, Italy

[13] AOU Citta Salute & Sci Torino, SC Chirurg Oncol Ortoped, Presidio CTO, Via Zuretti 29, I-10126 Turin, Italy

[14] IGEA Clin Biophys, Via Parmenide 10-A, I-41012 Carpi, MO, Italy

来源：

EJSO | 2021年 / 47卷 / 10期

关键词：

Electrochemotherapy (ECT); Bone metastases; Pain control; Palliative care; Metastatic bone disease (MBD); EMBOLIZATION;

D O I：

10.1016/j.ejso.2021.05.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a minimally invasive treatment. Preclinical and clinical studies supported the use of ECT in patients with metastatic bone disease (MBD). The purposes of this multicentre study are to confirm the safety and efficacy of ECT, and to identify appropriate operating procedures in different MBD conditions. Materials and methods: 102 patients were treated in 11 Centres and recorded in the REINBONE registry (a shared database protected by security passwords): clinical and radiological information, ECT session, adverse events, response, quality of life indicators and duration of follow-up were registered. Results: 105 ECT sessions were performed (one ECT session in 99 patients, two ECT sessions in 3 patients). 24 patients (23.5%) received a programmed intramedullary nail after ECT, during the same surgical procedure. Mean follow-up was 5.9 +/- 5.1 months (range 1.5-52). The response to treatment by RECIST criteria was 40.4% objective responses, 50.6% stable disease and 9% progressive disease. According to PERCIST criteria the response was: 31.4% OR; 51.7% SD, 16.9% PD with no significant differences between the 2 criteria. Diagnosis of breast cancer and ECOG values 0-1 were significantly associated to objective response. A significant decrease in pain intensity and significant better quality of life was observed after ECT session at follow-up. Conclusion: The results are encouraging on pain and tumour local control. ECT proved to be an effective and safe treatment for MBD and it should be considered as an alternative treatment as well as in combination with radiation therapy. (C) 2021 Elsevier Ltd, BASO - The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

引用

页码：2609 / 2617

页数：9

共 17 条

[1] Electrochemotherapy and Simultaneous Photodynamic Bone Stabilization of Upper Limbs in Metastatic Renal Cancer Disease: Case Report and Literature Review [J].