The underlying molecular mechanism of apolipoprotein E polymorphism - Relationships to lipid disorders, cardiovascular disease, and Alzheimer's disease

被引：37
作者：
Contois, JH [1 ]
Anamani, DE [1 ]
Tsongalis, GJ [1 ]
机构：
[1] HARTFORD HOSP, DEPT PATHOL & LAB MED, HARTFORD, CT 06102 USA
来源：
CLINICS IN LABORATORY MEDICINE | 1996年 / 16卷 / 01期
关键词：
D O I：
10.1016/S0272-2712(18)30290-7
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Apolipoprotein E (apo E) polymorphism has important clinical correlates, including disorders of Lipoprotein metabolism and atherosclerosis. This article provides a detailed methodology for apo E genotyping and discusses the link between apo E genotype and type III hyperlipoproteinemia, coronary heart disease (CHD), stroke, and Alzheimer's disease (AD). Although apo E genotype appears to provide significant information concerning the genetic component of CHD and AD risk, more research is needed before genotyping can be recommended as a routine screening tool. The data so far, however, implicate apo E as a major component of the genetic basis of cardiovascular disease and AD.
引用
收藏
页码：105 / +
页数：1
相关论文
共 109 条
[1]   THE LDL RECEPTOR RELATED PROTEIN, LRP, IS AN APOLIPOPROTEIN-E-BINDING PROTEIN [J].
BEISIEGEL, U ;
WEBER, W ;
IHRKE, G ;
HERZ, J ;
STANLEY, KK .
NATURE, 1989, 341 (6238) :162-164
[2]  
BOERWINKLE E, 1991, AM J HUM GENET, V49, P1145
[3]  
BOERWINKLE E, 1988, AM J HUM GENET, V42, P104
[4]   THE USE OF MEASURED GENOTYPE INFORMATION IN THE ANALYSIS OF QUANTITATIVE PHENOTYPES IN MAN .2. THE ROLE OF THE APOLIPOPROTEIN-E POLYMORPHISM IN DETERMINING LEVELS, VARIABILITY, AND COVARIABILITY OF CHOLESTEROL, BETA-LIPOPROTEIN, AND TRIGLYCERIDES IN A SAMPLE OF UNRELATED INDIVIDUALS [J].
BOERWINKLE, E ;
VISVIKIS, S ;
WELSH, D ;
STEINMETZ, J ;
HANASH, SM ;
SING, CF .
AMERICAN JOURNAL OF MEDICAL GENETICS, 1987, 27 (03) :567-582
[5]   A RECEPTOR-MEDIATED PATHWAY FOR CHOLESTEROL HOMEOSTASIS [J].
BROWN, MS ;
GOLDSTEIN, JL .
SCIENCE, 1986, 232 (4746) :34-47
[6]   THE RESPONSE TO LOVASTATIN TREATMENT IN PATIENTS WITH HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA IS MODULATED BY APOLIPOPROTEIN-E POLYMORPHISM [J].
CARMENA, R ;
ROEDERER, G ;
MAILLOUX, H ;
LUSSIERCACAN, S ;
DAVIGNON, J .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1993, 42 (07) :895-901
[7]   RAPID AND SAFE DETERMINATION OF HUMAN APOLIPOPROTEIN-E GENOTYPES BY MINIATURIZED SDS-PAGE IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS [J].
CLAVEL, C ;
DURLACH, A ;
DURLACH, V ;
BIREMBAUT, P .
JOURNAL OF CLINICAL PATHOLOGY, 1995, 48 (04) :295-299
[8]  
COBB MM, 1991, CIRCULATION, V86, P145
[9]   GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].
CORDER, EH ;
SAUNDERS, AM ;
STRITTMATTER, WJ ;
SCHMECHEL, DE ;
GASKELL, PC ;
SMALL, GW ;
ROSES, AD ;
HAINES, JL ;
PERICAKVANCE, MA .
SCIENCE, 1993, 261 (5123) :921-923
[10]   PREVALENCE OF APOLIPOPROTEIN-E PHENOTYPES IN ISCHEMIC CEREBROVASCULAR-DISEASE - A CASE-CONTROL STUDY [J].
COUDERC, R ;
MAHIEUX, F ;
BAILLEUL, S ;
FENELON, G ;
MARY, R ;
FERMANIAN, J .
STROKE, 1993, 24 (05) :661-664
12345678910