A new stereocontrolled, pyrylium-based route to conjugated dienynes: The first synthesis of Carduusyne A

被引：20

作者：

Charoenying, P

Davies, H

McKerrecher, D

Taylor, RJK

机构：

[1] UNIV YORK,DEPT CHEM,YORK YO1 5DD,N YORKSHIRE,ENGLAND

[2] ZENECA PHARMACEUT,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 11期

关键词：

D O I：

10.1016/0040-4039(96)00153-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new stereocontrolled route to conjugated dienynes is described utilising organometallic addition to pyrylium salts followed by Wittig homologation and dehydrohalogenation. The utility of this methodology is illustrated in the first total synthesis of the marine metabolite Carduusyne A.

引用

页码：1913 / 1916

页数：4

共 23 条

[1]

ABRAMS SR, 1987, ORG SYNTH, V66, P127

[2] CONVENIENT GENERAL-METHOD FOR THE PREPARATION OF PRIMARY ALKYLLITHIUMS BY LITHIUM IODINE EXCHANGE [J].