Microarrays: biotechnology's discovery platform for functional genomics

被引：567

作者：

Schena, M ^{[1
]}

Heller, RA

Theriault, TP

Konrad, K

Lachenmeier, E

Davis, RW

机构：

[1] Stanford Univ, Med Ctr, Beckman Ctr, Dept Biochem, Stanford, CA 94305 USA

[2] Roche Biosci, Palo Alto, CA 94304 USA

[3] Incyte Pharmaceut, Palo Alto, CA 94304 USA

来源：

TRENDS IN BIOTECHNOLOGY | 1998年 / 16卷 / 07期

关键词：

D O I：

10.1016/S0167-7799(98)01219-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Advances in microarray technology enable massive parallel mining of biological data, with biological chips providing hybridization-based expression monitoring, polymorphism detection and genotyping on a genomic scale. Microarrays containing sequences representative of all human genes may soon permit the expression analysis of the entire human genome in a single reaction. These 'genome chips' will provide unprecedented access to key areas of human health, including disease prognosis and diagnosis, drug discovery, toxicology, aging, and mental illness. Microarray technology is rapidly becoming a central platform for functional genomics.

引用

页码：301 / 306

页数：6

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