In Vitro Drug Release and Biocatalysis from pH-Responsive Gold Nanoparticles Synthesized Using Doxycycline

被引：16

作者：

Kazmi, Syed Akif Raza ^{[1
,3
]}

Qureshi, Muhammad Zahid ^{[1
]}

Ali, Shaukat ^{[2
]}

Masson, Jean-Francois ^{[3
]}

机构：

[1] Govt Coll Univ Lahore, Dept Chem, Lahore 54000, Pakistan

[2] Govt Coll Univ Lahore, Dept Zool, Lahore 54000, Pakistan

[3] Univ Montreal, Dept Chim, CP 6128 Succ Ctr Ville, Montreal, PQ H3C 3J7, Canada

来源：

LANGMUIR | 2019年 / 35卷 / 49期

基金：

加拿大自然科学与工程研究理事会;

关键词：

DOPAMINE; DELIVERY; DOXORUBICIN; OXIDATION; SHELL; NANOCOMPOSITES; VEHICLES; SYSTEM; ACID; DOTS;

D O I：

10.1021/acs.langmuir.9b02420

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

pH-sensitive doxycycline gold nanoparticles (doxy-AuNPs) are reported here to act as effective drug nanocarriers and as biocatalysts. The AuNPs were synthesized with doxy as the reducing and capping agent. Various parameters were optimized to find the best conditions for the synthesis of doxy-AuNPs, and these were characterized with UV-vis, X-ray diffraction (XRD), FTIR, and transmission electron microscopy (TEM). Doxy-AuNPs were then loaded with the anticancer drug doxorubicin (DOX), where 70% of the initially available drug was loaded within 24 h. Furthermore, pH-dependent drug release was measured at 60% with in vitro measurements in phosphate-buffered saline (PBS). In addition, the doxy-AuNPs were applied as a biocatalyst. Oxidation of dopamine was taken as a model reaction to determine the catalytic activity of doxy-AuNPs. Almost complete oxidation of dopamine occurred in 5 min, which indicates the fast response of synthesized doxy-AuNPs as a biocatalyst. Hence, doxy-AuNPs are a versatile platform for drug loading and biocatalyst.

引用

页码：16266 / 16274

页数：9

共 61 条

[1] pH Triggered Recovery and Reuse of Thiolated Poly(acrylic acid) Functionalized Gold Nanoparticles with Applications in Colloidal Catalysis [J].