Orthohepevirus C: An Expanding Species of Emerging Hepatitis E Virus Variants

被引：54
作者：
Wang, Bo [1 ]
Harms, Dominik [2 ]
Yang, Xing-Lou [3 ]
Bock, C. -Thomas [2 ,4 ]
机构：
[1] Virginia Polytech Inst & State Univ, Virginia Maryland Coll Vet Med, Dept Biomed Sci & Pathobiol, Blacksburg, VA 24061 USA
[2] Robert Koch Inst, Div Viral Gastroenteritis & Hepatitis Pathogens &, Dept Infect Dis, D-13353 Berlin, Germany
[3] Chinese Acad Sci, Ctr Biosafety Mega Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens, Wuhan 430071, Peoples R China
[4] Univ Tubingen, Inst Trop Med, D-72074 Tubingen, Germany
来源：
PATHOGENS | 2020年 / 9卷 / 03期
关键词：
Orthohepevirus C; hepatitis E virus; genetic variability; molecular evolution; host; zoonosis; WILD NORWAY RATS; SEROLOGICAL EVIDENCE; WIDESPREAD INFECTION; RATTUS-RATTUS; GENOTYPES; IDENTIFICATION; PREVALENCE; RODENTS; STRAIN; FERRETS;
D O I：
10.3390/pathogens9030154
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Hepatitis E virus (HEV) is an emerging zoonotic pathogen that has received an increasing amount of attention from virologists, clinicians, veterinarians, and epidemiologists over the past decade. The host range and animal reservoirs of HEV are rapidly expanding and a plethora of emerging HEV variants have been recently identified, some of which have the potential for interspecies infection. In this review, the detection of genetically diverse HEV variants, classified into and presumably associated with the species Orthohepevirus C, currently comprising HEV genotypes C1 and C2, by either serological or molecular approach is summarized. The distribution, genomic variability, and evolution of Orthohepevirus C are analyzed. Moreover, the potential risk of cross-species infection and zoonotic transmission of Orthohepevirus C are discussed.
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