LARGE CELL METASTATIC PANCREATIC NEUROENDOCRINE CARCINOMA TREATED WITH SOMATOSTATIN ANALOGUES - CASE REPORT AND LITERATURE REVIEW

被引：0

作者：

Croitoru, A. ^{[1
,7
]}

Dinu, I ^{[1
]}

Herlea, V ^{[2
]}

Becheanu, G. ^{[2
]}

Grasu, M. ^{[3
]}

Lupescu, I ^{[3
]}

Dima, S. O. ^{[4
,5
]}

Buica, F. ^{[1
,7
]}

Dumitrascu, T. ^{[4
]}

Lungulescu, C. ^{[8
]}

Croitoru, V. M. ^{[1
]}

Tanase, A. ^{[6
,7
]}

Negru, S. M. ^{[9
]}

Gramaticu, I. M. ^{[1
]}

机构：

[1] Titu Maiorescu Univ, Dept Med Oncol, Fundeni Clin Inst, Bucharest, Romania

[2] Titu Maiorescu Univ, Dept Pathol, Bucharest, Romania

[3] Titu Maiorescu Univ, Dept Radiol & Med Imaging, Bucharest, Romania

[4] Titu Maiorescu Univ, Ctr Gen Surg & Liver Transplantat, Bucharest, Romania

[5] Titu Maiorescu Univ, Ctr Excellence Translat Med, Bucharest, Romania

[6] Titu Maiorescu Univ, Bone Marrow Transplant Ctr, Bucharest, Romania

[7] Titu Maiorescu Univ, Fac Med, Bucharest, Romania

[8] Dolj Cty Emergency Hosp, Dept Oncol, Craiova, Romania

[9] Victor Babes Univ Med & Pharm, Timisoara, Romania

来源：

ACTA ENDOCRINOLOGICA-BUCHAREST | 2019年 / 15卷 / 03期

关键词：

Nueorendocrine tumor; Large cell pancreatic carcinoma; lanreotide autogel; ENETS CONSENSUS GUIDELINES; 1ST-LINE CHEMOTHERAPY; PROGNOSTIC-FACTORS; ETOPOSIDE; LANREOTIDE; CISPLATIN; TUMORS; G3; PROLIFERATION; MANAGEMENT;

D O I：

10.4183/aeb.2019.390

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report the case of a 55-year-old-male with a large cell metastatic pancreatic neuroendocrine carcinoma treated for 14 months with lanreotide autogel having a stable disease (SD) and not responding to chemotherapy. The somatostatin analogues (SSA) were introduced after an episode of diarrhea and controlled the disease. Progression-free survival (PFS) as determined by Computerized Tomography (CT) scans was obtained for 14 months. After more than a year, the patient's health state deteriorated along with progressive disease. The capecitabine-temozolomide regimen was challenged, but after three cycles, a rapid clinical decline was noted. Conclusion. This unexpected event (diarrhea) in the course of the disease could represent the beginning of carcinoid syndrome. While the lanreotide autogel helped the episode of diarrhea pass, it also helped gain control over the disease itself.

引用

页码：390 / 397

页数：8

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