Effect of all-trans retinoic acid on the barrier function in human retinal pigment epithelial cells

被引：20
|
作者：
Rong, Junbo [1 ]
Liu, Shuangzhen [1 ]
机构：
[1] Cent S Univ, Xiangya Hosp, Dept Ophthalmol, Changsha, Hunan, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2011年 / 407卷 / 03期
关键词：
ARPE-19; cells; All-trans retinoic acid; Tight junction; Barrier function; EXPERIMENTALLY-INDUCED MYOPIA; ALTERED EYE GROWTH; IN-VITRO; CHOROIDAL THICKNESS; DEPRIVATION MYOPIA; INDUCED INHIBITION; RECEPTOR-ALPHA; CHICK; DIFFERENTIATION; PROLIFERATION;
D O I：
10.1016/j.bbrc.2011.03.080
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To investigate the effects of all-trans retinoic acid (atRA) on the barrier function in human retinal pigment epithelial cells. ARPE-19 cells were cultured on the filters as monolayer with atRA being added in the apical side. The change of epithelial permeability was observed from the measurement of transepithelial electrical resistance (TER), permeability assay, and Western Blot analysis. We discovered that atRA promoted the epithelial barrier function in vitro, and its bioavailability regulates the epithelial barrier, which is accompanied by altering expression of tight junctions (TJ)-associated proteins. Our study indicates that atRA provides barrier-positive elements to the RPE cell. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：605 / 609
页数：5
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