Synthesis and characterization of flavin-tethered peptide nucleic acid

被引：26

作者：

Ikeda, H ^{[1
]}

Yoshida, K ^{[1
]}

Ozeki, M ^{[1
]}

Saito, I ^{[1
]}

机构：

[1] Kyoto Univ, CREST,Japan Sci & Technol Corp, Fac Engn, Dept Synthet Chem & Biol Chem, Kyoto 6068501, Japan

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(01)00228-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We synthesized flavin-containing PNA. monomer unit 5 from lumiflavin and prepared PNAs containing a flavin moiety (FPNA) by the standard tBoc chemistry. Each PNA oligomer was purified by reversed-phase HPLC and characterized by MALDI-TOF MS and UV spectra. Thermodynamic analyses indicated that the PNA oligomer containing a flavin moiety near the amino terminal considerably stabilized the PNA-DNA hybrids. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：2529 / 2531

页数：3

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