Vitamins deficiency in developing chick during chromium intoxication and protection thereof

被引：3

作者：

Chundawat, RS ^{[1
]}

Sood, PP ^{[1
]}

机构：

[1] Saurashtra Univ, Dept Biosci, Lab Neurobiol & Toxicol, Rajkot 360005, Gujarat, India

来源：

TOXICOLOGY | 2005年 / 211卷 / 1-2期

关键词：

vitamins deficiency; chromium; protection;

D O I：

10.1016/j.tox.2005.03.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Deficiency of various vitamins in postnatally developing chick during chromium intoxication and their recovery during vitamins (B and E) and glutathione therapies has been investigated. Study was concentrated on liver, kidney, muscles and serum. Newly hatched chicks were reared in laboratory. They were treated with a daily dose of 10 mg/kg/day potassium dichromate from 2nd to 8th day of their age. Thereafter, one group was sacrificed on 9th day. Second group was kept without intoxication for another 7 days and sacrificed on 16th day. Three groups of chromium pretoxicated animals were exposed to therapeutic agents like vitamins (B and E) and glutathione for another 7 days. These animals were sacrificed on 16th day of their age along with control. Study showed chromium intoxication decreases vitamins (B-1, B-2, B-6 and E) in all the tissues and serum. The maximum decrease was recorded in serum. The 7 days pretoxicated animals kept without any treatment for 7 days revealed a slow increase of vitamins with few exceptions. Nevertheless, the recovery of vitamins was quick and significant during vitamins and glutathione therapy and in some cases control level was achieved. (c) 2005 Elsevier Ireland Ltd, All rights reserved.

引用

页码：124 / 131

页数：8

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