An efficient synthesis, characterization and anti-bacterial activity of pyrimidine bearing 1,3,4-thiadiazole derivatives

被引:0
作者
Andrews, B. [1 ,2 ]
Ahmed, Mansur [1 ]
机构
[1] Islamiah Coll, PG & Res Dept Chem, Vaniyambadi 635752, India
[2] Priyadarshini Engn Coll, Dept Chem, Vaniyambadi 635751, India
来源
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2015年 / 54卷 / 03期
关键词
Pyrimidine; thiadiazole; hydrazine carbothioamide; antibacterial activity; TRIAZOLE;
D O I
暂无
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A series of pyrimidine bearing 1,3,4-thiadiazole derivatives have been synthesized and evaluated for antibacterial activity. All the structures of the newly synthesized compounds have been supported by IR, H-1 and C-13 NMR, GC-MS and CHN analysis. Most of the compounds have shown promising antibacterial activity when compared with the standard drug Ciprofloxacin.
引用
收藏
页码:406 / 411
页数:6
相关论文
共 27 条
[1]   Novel Synthesis and Characterization of Some Pyrimidine Derivatives of Oxadiazoles, Triazole and 1,3,4-Thiadiazoles [J].
Andrews, B. ;
Ahmed, Mansur .
ASIAN JOURNAL OF CHEMISTRY, 2013, 25 (04) :2070-2072
[2]  
Andrews B., 2012, J. Chem. Pharm. Res, V4, P3920
[3]  
ATKINSON RO, 1954, J CHEM SOC, P1329
[4]  
Desai NC, 2008, INDIAN J CHEM B, V47, P579
[5]   Biginelli reaction starting directly from alcohols [J].
Garima ;
Srivastava, Vishnu P. ;
Yadav, Lal Dhar S. .
TETRAHEDRON LETTERS, 2010, 51 (49) :6436-6438
[6]   Synthesis of Acyclic Nucleosides with a Chiral Amino Side Chain by the Mitsunobu Coupling Reaction [J].
Guo, Hai-Ming ;
Wu, Yan-Yan ;
Niu, Hong-Ying ;
Wang, Dong-Chao ;
Qu, Gui-Rong .
JOURNAL OF ORGANIC CHEMISTRY, 2010, 75 (11) :3863-3866
[7]   UBER N-MANNICH-BASEN .1. MANNICH-BASEN VON CYCLISCHEN AMIDEN UND AMINEN [J].
HELLMANN, H ;
LOSCHMANN, I .
CHEMISCHE BERICHTE-RECUEIL, 1954, 87 (11) :1684-1690
[8]  
Jagadhani SG, 2006, INDIAN J HETEROCY CH, V15, P335
[9]  
KAPPE CO, 1993, TETRAHEDRON, V49, P6937
[10]   Biologically active dihydropyrimidones of the Biginelli-type - a literature survey [J].
Kappe, CO .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2000, 35 (12) :1043-1052