Synthesis of 1-oxo-1-(3-pyridazinyl) derivatives - potent inhibitors of fatty acid amide hydrolase (FAAH): an improved and optimized procedure

被引：4
作者：
Rosini, Goffredo
Andreotti, Daniele G.
D'Ambrosio, Primiano
Marotta, Emanuela
Tinarelli, Alessandro
Righi, Paolo
机构：
[1] Univ Bologna, Dipartimento Chim Organ A Mangini, Alma Mater Studiorum, I-40136 Bologna, Italy
[2] GlaxoSmithKline Inc, Med Res Ctr, I-37135 Verona, Italy
来源：
SYNTHESIS-STUTTGART | 2007年 / 19卷 / 19期
关键词：
3-acylpyridazines; regioselective acylations; FAAH inhibitors; Weinreb amides; lithiation; drugs;
D O I：
10.1055/s-2007-990774
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A greatly improved procedure for the preparation of long-chain alpha-ketopyridazines, a class of potent inhibitors of fatty acid amide hydrolase (FAAH), is described. This optimization study shows a great dependence of the yields of desired products on the pyrididazinyl lithium/Weinreb amide ratio and offers a general approach to this kind of compound.
引用
收藏
页码：3051 / 3055
页数：5
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