Long-term cyclosporin A pharmacokinetic profiles in pediatric renal transplant recipients

被引:0
作者
Kelles, A [1 ]
VanDammeLombaerts, R [1 ]
TjandraMaga, TB [1 ]
VanDamme, B [1 ]
机构
[1] UNIV HOSP GASTHUISBERG, DEPT PEDIAT NEPHROL, B-3000 LOUVAIN, BELGIUM
关键词
cyclosporin A; renal transplantation; children; CyA; pediatric; pharmacokinetics;
D O I
暂无
中图分类号
R61 [外科手术学];
学科分类号
摘要
To study the long-term effect of cyclosporin A (CyA), 94 6-h and 29 12-h pharmacokinetic profiles were evaluated in 32 children at least 1 year after renal transplantation. Children weighing less than 25 kg needed significantly higher doses of CyA than those weighing more than 25 kg(9.8 vs 5.3 mg/kg per day; P < 0.001) to achieve similar trough levels (TL). The average dose of CyA required to achieve the target TL declined gradually with time after transplantation. The average area under the curve over 6 h (AUC/6) correlated strongly with the AUC/12 (r = 0.967, P < 0.001). The AUC/6 of patients with biopsy-proven CyA toxicity was significantly higher than for those without, toxicity (Mann-Whitney U-test P < 0.05) despite similar TL. We conclude that AUC monitoring for 6 h provides valuable information not only on TL but also on the absorption and elimination characteristics of CyA as well as on the potential for CyA toxicity.
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页码:546 / 550
页数:5
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