Mutagenic activity of quaternary ammonium salt derivatives of carbohydrates

被引：6
作者：
Dmochowska, Barbara [1 ]
Sikora, Karol [1 ,2 ]
Woziwodzka, Anna [3 ,4 ]
Piosik, Jacek [3 ,4 ]
Podgorska, Beata [5 ]
机构：
[1] Univ Gdansk, Fac Chem, Wita Stwosza 63, PL-80308 Gdansk, Poland
[2] Med Univ Gdansk, Fac Pharm, Gen Hallera 107, PL-80416 Gdansk, Poland
[3] Univ Gdansk, Intercollegiate Fac Biotechnol, Lab Biophys, Antoniego Abrahama 58, PL-80307 Gdansk, Poland
[4] Med Univ Gdansk, PL-80307 Gdansk, Poland
[5] Univ Gdansk, Dept Mol Evolut, Wita Stwosza 59, PL-80308 Gdansk, Poland
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 12卷
关键词：
6-bromohexyl D-glucopyranoside; microbiological mutagenicity test; quaternary ammonium salt; IONIC LIQUIDS; CHITOSAN; BIODEGRADABILITY; SURFACTANTS; TOXICITY; RESIDUES; CANCER; CELLS;
D O I：
10.3762/bjoc.12.138
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This paper presents a study on a series of quaternary ammonium salt (QAS) derivatives of glucopyranosides with an elongated hydrophobic hydrocarbon chain. The new N-[6-(beta-D-glucopyranosyloxy)hexyl]ammonium bromides and their O-acetyl derivatives were analyzed via H-1 and C-13 NMR spectroscopy. The mutagenic activity of the newly synthesized QAS was investigated using two different techniques: The Vibrio harveyi luminescence assay and the Ames test. The obtained results support previous findings contesting QAS safety and indicate that QAS, specifically pyridinium derivatives, might be mutagenic.
引用
收藏
页码：1434 / 1439
页数：6
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