Anticancer activity of limonoid from Khaya senegalensis

被引：59

作者：

Zhang, Huaping

Wang, Xi

Chen, Feng ^{[1
]}

Androulakis, Xiao M.

Wargovich, Michael J.

机构：

[1] Clemson Univ, Dept Food Sci & Human Nutr, Clemson, SC 29634 USA

[2] Clemson Univ, Dept Biochem & Genet, Clemson, SC 29634 USA

[3] Univ S Carolina, Sch Med, Dept Pathol & Microbiol, S Carolina Canc Ctr, Columbia, SC 29208 USA

来源：

PHYTOTHERAPY RESEARCH | 2007年 / 21卷 / 08期

关键词：

Khaya senegalensis; Meliaceae; limonoid; 3; alpha; 7; alpha-dideacetylkhivorin; 1-O-acetylkhayanolide B; antiproliferative activity; ANTIFUNGAL ACTIVITY; MEDICINAL-PLANTS; STEM BARK; IN-VITRO; MELIACEAE; EXTRACT; CHEMISTRY;

D O I：

10.1002/ptr.2148

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two limonoids were isolated from the methanol extract of Khaya senegalensis (Meliaceae), and their structures were identified as 3 alpha,7 alpha-dideacetylkhivorin (1) and 1-O-acetylkhayanolide B (2) on the basis of MS and NMR spectral data. Complete assignments of H-1 and C-13 chemical shifts for compounds 1 and 2 were achieved by means of ID and 2D NMR including DEPT, H-1-H-1 COSY, HMQC, HMBC experiments. Compound I showed significant growth inhibitory activities against MCF-7, SiHa and Caco-2 cells with IC50 values in the range of 0.07-0.14 mu m (35-69 ppm) while compound 2 did not. Copyright (c) 2007 John Wiley & Sons, Ltd.

引用

页码：731 / 734

页数：4

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