Expression of TAK1, a mediator of TGF-β and BMP signaling, during mouse embryonic development

被引：30
作者：
Jadrich, JL
O'Connor, MB
Coucouvanis, E [1 ]
机构：
[1] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Stem Cell Inst, Minneapolis, MN 55455 USA
来源：
GENE EXPRESSION PATTERNS | 2003年 / 3卷 / 02期
关键词：
TAK1; mouse embryo; immunohistochemistry; nervous system; testis; kidney; liver; gut; lung; pancreas;
D O I：
10.1016/S1567-133X(03)00012-7
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
TGF-beta activated kinase I (TAK1) is a MAP kinase kinase kinase (MAPKKK) that has been shown to function downstream of BMPs and TGF-beta (J. Biol. Chem. 275 (2000) 17647; EMBO J. 17 (1998) 1019; Science 270 (1995) 2008), as well as in the interleukin-1 (IL-1) signaling pathway (J. Biol. Chem. 276 (2001) 3508; Nature 398 (1999) 252). Using immunohistochemistry (IHC), we demonstrate that TAK1 is expressed ubiquitously during early development. At mid-gestation, TAK1 expression becomes more restricted, with high levels seen specifically during development of diverse organs and tissues including the nervous system, testis, kidney, liver and gut. Additionally, TAK1 expression is seen in the developing lung and pancreas. Our results suggest that TAK1 may play multiple roles in mouse development. (C) 2003 Elsevier Science B.V. All rights reserved.
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页码：131 / 134
页数：4
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