POINT SHEAR WAVE ELASTOGRAPHY FOR NON-INVASIVE ASSESSMENT OF LIVER FIBROSIS IN PATIENTS WITH VIRAL HEPATITIS

被引：13

作者：

Bucsics, Theresa ^{[1
,2
]}

Grasl, Benjamin ^{[1
,2
]}

Ferlitsch, Arnulf ^{[1
,2
,3
]}

Schwabl, Philipp ^{[1
,2
]}

Mandorfer, Mattias ^{[1
,2
]}

Zinober, Kerstin ^{[1
,2
]}

Stern, Rafael ^{[1
,4
]}

Chromy, David ^{[1
,2
]}

Scheiner, Bernhard ^{[1
,2
]}

Sieghart, Wolfgang ^{[1
,2
]}

Peck-Radosavljevic, Markus ^{[1
,2
,5
]}

Trauner, Michael ^{[1
]}

Reiberger, Thomas ^{[1
,2
]}

机构：

[1] Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, Vienna, Austria

[2] Med Univ Vienna, Hepat Hemodynam Lab, Vienna, Austria

[3] Krankenhaus Barmherzigen Bruder Wien, Dept Internal Med, Vienna, Austria

[4] Krankenhaus Oberpullendorf, Dept Internal Med, Oberpullendorf, Austria

[5] Klinikum Klagenfurt Woerthersee, Dept Gastroenterol Hepatol Endocrinol & Nephrol, Klagenfurt, Austria

来源：

ULTRASOUND IN MEDICINE AND BIOLOGY | 2018年 / 44卷 / 12期

关键词：

Liver fibrosis; Viral hepatitis; Transient elastography; Shear wave elastography; TRANSIENT ELASTOGRAPHY; PORTAL-HYPERTENSION; GLOBAL BURDEN; CIRRHOSIS; DISEASE; PREDICT; RELIABILITY; PROGRESSION; STIFFNESS; IMPROVE;

D O I：

10.1016/j.ultrasmedbio.2018.07.031

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

Elastography point quantification (ElastPQ) is a new ultrasound-based shear wave elastography method for non-invasive assessment of liver fibrosis. We evaluated the diagnostic accuracy of ElastPQ in patients with chronic viral hepatitis. Fibrosis stage (F) was determined by transient elastography (F0/F1: <7.1 kPa, F2: 7.1-9.4 kPa, F3: 9.5-12.4 kPa, F4: >= 12.5 kPa). Area under the receiver operator characteristics curve (AUROC) analysis was performed to assess ElastPQ cutoffs for significant fibrosis (>= F2) and cirrhosis (F4). Paired transient elastography and ElastPQ measurements were obtained from 217 patients (mean age +/- SEM: 49 +/- 0.79 years, 68.2% male, F0/F1: n = 98 145.0%], F2: 47 [21.6%], F3: 22 [10.1%1, F4: 50 [22.9%]). AUROC for >= F2 was 0.843 (95% confidence interval: 0.791-0.895), and for F4, 0.933 (95% confidence interval: 0.894-0.972). The optimal ElastPQ cutoff for F2 was 6.68 kPa (sensitivity: 80.7%, specificity: 70.4%, positive predictive value: 78.5%, negative predictive value: 72.3%), and for F4 11.28 kPa (sensitivity: 86.0%, specificity: 85.6%, positive predictive value: 60.52%, negative predictive value: 97.16%). In conclusion, ElastPQ represents an accurate tool for non-invasive staging of liver fibrosis in patients with viral hepatitis. (C) 2018 World Federation for Ultrasound in Medicine & Biology. All rights reserved.

引用

页码：2578 / 2586

页数：9

共 44 条

[1] Exposure to previous cART is associated with significant liver fibrosis and cirrhosis in human immunodeficiency virus-infected patients [J].