Biological and clinical role of p73 in neuroblastoma

被引：16
|
作者：
Romani, A
Tonini, GP
Banelli, B
Allemanni, G
Mazzocco, K
Scaruffi, P
Boni, L
Ponzoni, M
Pagnan, G
Raffaghello, L
Ferrini, S
Croce, M
Casciano, I
机构：
[1] Ist Nazl Ric Canc, IST, Lab Tumor Genet, I-16132 Genoa, Italy
[2] CBA, Neuroblastoma Res Lab, I-16132 Genoa, Italy
[3] CBA, Biomed Technol Assessment, I-16132 Genoa, Italy
[4] Ist Giannina Gaslini, Differentiat Therapy Unit, I-16147 Genoa, Italy
[5] Ist Nazl Ric Canc, IST, Lab Immunopharmacol, I-16132 Genoa, Italy
来源：
CANCER LETTERS | 2003年 / 197卷 / 1-2期
关键词：
neuroblastoma; p73; apoptosis; tumor suppressor gene; methylation;
D O I：
10.1016/S0304-3835(03)00092-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The p73 gene is a p53 homologue localized at 1p36.3, a chromosomal region frequently deleted in neuroblastoma. p73 was originally considered an oncosuppressor gene. However, it was soon realized that its mode of action did not resemble that of a classic anti-oncogene. The recent discovery of N-terminal truncated isoforms, with oncogenic properties, showed that p73 has a 'two in one' structure. Indeed, the full-length variants are strong inducers of apoptosis while the truncated isoforms inhibit the pro-apoptotic activity of p53 and of the full-length p73. This review summarizes some aspects of p73 biology with particular reference to its possible role in neuroblastoma. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：111 / 117
页数：7
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