Biological and clinical role of p73 in neuroblastoma

被引：16

作者：

Romani, A

Tonini, GP

Banelli, B

Allemanni, G

Mazzocco, K

Scaruffi, P

Boni, L

Ponzoni, M

Pagnan, G

Raffaghello, L

Ferrini, S

Croce, M

Casciano, I

机构：

[1] Ist Nazl Ric Canc, IST, Lab Tumor Genet, I-16132 Genoa, Italy

[2] CBA, Neuroblastoma Res Lab, I-16132 Genoa, Italy

[3] CBA, Biomed Technol Assessment, I-16132 Genoa, Italy

[4] Ist Giannina Gaslini, Differentiat Therapy Unit, I-16147 Genoa, Italy

[5] Ist Nazl Ric Canc, IST, Lab Immunopharmacol, I-16132 Genoa, Italy

来源：

CANCER LETTERS | 2003年 / 197卷 / 1-2期

关键词：

neuroblastoma; p73; apoptosis; tumor suppressor gene; methylation;

D O I：

10.1016/S0304-3835(03)00092-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The p73 gene is a p53 homologue localized at 1p36.3, a chromosomal region frequently deleted in neuroblastoma. p73 was originally considered an oncosuppressor gene. However, it was soon realized that its mode of action did not resemble that of a classic anti-oncogene. The recent discovery of N-terminal truncated isoforms, with oncogenic properties, showed that p73 has a 'two in one' structure. Indeed, the full-length variants are strong inducers of apoptosis while the truncated isoforms inhibit the pro-apoptotic activity of p53 and of the full-length p73. This review summarizes some aspects of p73 biology with particular reference to its possible role in neuroblastoma. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：111 / 117

页数：7

共 50 条

[21] An essential role for p73 in regulating mitotic cell death
W H Toh
S Y Nam
K Sabapathy
Cell Death & Differentiation, 2010, 17 : 787 - 800
[22] When p53 needs p73 to be functional -: forced p73 expression induces nuclear accumulation of endogenous p53 protein
Goldschneider, D
Blanc, E
Raguenez, G
Haddada, H
Bénard, J
Douc-Rasy, S
CANCER LETTERS, 2003, 197 (1-2) : 99 - 103
[23] p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent
Ichimiya, S
Nimura, Y
Kageyama, H
Takada, N
Sunahara, M
Shishikura, T
Nakamura, Y
Sakiyama, S
Seki, N
Ohira, M
Kaneko, Y
McKeon, F
Caput, D
Nakagawara, A
ONCOGENE, 1999, 18 (04) : 1061 - 1066
[24] p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent
Shingo Ichimiya
Yoshinori Nimura
Hajime Kageyama
Naoyuki Takada
Masao Sunahara
Tomotane Shishikura
Yohko Nakamura
Shigeru Sakiyama
Naohiko Seki
Miki Ohira
Yasuhiko Kaneko
Frank McKeon
Daniel Caput
Akira Nakagawara
Oncogene, 1999, 18 : 1061 - 1066
[25] P73, the "assistant" guardian of the genome?
Melino, G
APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS, 2003, 1010 : 9 - 15
[26] Structure and apoptotic function of p73
Yoon, Mi-Kyung
Ha, Ji-Hyang
Lee, Min-Sung
Chi, Seung-Wook
BMB REPORTS, 2015, 48 (02) : 81 - 90
[27] Differential response of p53 target genes to p73 overexpression in SH-SY5Y neuroblastoma cell line
Goldschneider, D
Blanc, E
Raguénez, G
Barrois, M
Legrand, A
Le Roux, G
Haddada, H
Bénard, J
Douc-Rasy, S
JOURNAL OF CELL SCIENCE, 2004, 117 (02) : 293 - 301
[28] Transactivation-deficient p73α (p73Δexon2) inhibits apoptosis and competes with p53
Igor Fillippovich
Natasha Sorokina
Magtouf Gatei
Ygal Haupt
Karen Hobson
Eli Moallem
Kevin Spring
Michelle Mould
Michael A McGuckin
Martin F Lavin
Kum Kum Khanna
Oncogene, 2001, 20 : 514 - 522
[29] Transactivation-deficient p73α (p73Δexon2) inhibits apoptosis and competes with p53
Fillippovich, I
Sorokina, N
Gatei, M
Haupt, Y
Hobson, K
Moallem, E
Spring, K
Mould, M
McGuckin, MA
Lavin, MF
Khanna, KK
ONCOGENE, 2001, 20 (04) : 514 - 522
[30] p53 and p73 in suppression of Myc-driven lymphomagenesis
Griesmann, Heidi
Schlereth, Katharina
Krause, Michael
Samans, Birgit
Stiewe, Thorsten
INTERNATIONAL JOURNAL OF CANCER, 2009, 124 (02) : 502 - 506

← 1 2 3 4 5 →