Crystal structure of ABT-737 complexed with Bcl-xL:: implications for selectivity of antagonists of the Bcl-2 family

被引：218

作者：

Lee, E. F.

Czabotar, P. E.

Smith, B. J.

Deshayes, K.

Zobel, K.

Colman, P. M.

Fairlie, W. D.

机构：

[1] Walter & Eliza Hall Inst Med Res, Struct Biol Div, Parkville, Vic 3050, Australia

[2] Univ Melbourne, Dept Med Biol, Parkville, Vic 3052, Australia

[3] Genentech Inc, San Francisco, CA 94080 USA

来源：

CELL DEATH AND DIFFERENTIATION | 2007年 / 14卷 / 09期

关键词：

D O I：

10.1038/sj.cdd.4402178

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：1711 / 1713

页数：3

共 17 条

[1] Studies leading to potent, dual inhibitors of bcl-2 and Bcl-xL [J].

Bruncko, Milan ;

Oost, Thorsten K. ;

Belli, Barbara A. ;

Ding, Hong ;

Joseph, Mary K. ;

Kunzer, Aaron ;

Martineau, Darlene ;

McClellan, William J. ;

Mitten, Michael ;

ng, Shi-Chu Ng ;

Nimmer, Paul M. ;

Oltersdorf, Tilman ;

Park, Cheol-Min ;

Petros, Andrew M. ;

Shoemaker, Alexander R. ;

Song, Xiaohong ;

Wang, Xilu ;

Wendt, Michael D. ;

Zhang, Haichao ;

Fesik, Stephen W. ;

Rosenberg, Saul H. ;

Elmore, Steven W. .

JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (04) :641-662

[2] A novel Bcl-2/Bcl-XL/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma [J].

Chauhan, D. ;

Velankar, M. ;

Brahmandam, M. ;

Hideshima, T. ;

Podar, K. ;

Richardson, P. ;

Schlossman, R. ;

Ghobrial, I. ;

Raje, N. ;

Munshi, N. ;

Anderson, K. C. .

ONCOGENE, 2007, 26 (16) :2374-2380

[3] Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function [J].

Chen, L ;

Willis, SN ;

Wei, A ;

Smith, BJ ;

Fletcher, JI ;

Hinds, MG ;

Colman, PM ;

Day, CL ;

Adams, JM ;

Huang, DCS .

MOLECULAR CELL, 2005, 17 (03) :393-403

[4] The Bcl-2 family: roles in cell survival and oncogenesis [J].

Cory, S ;

Huang, DCS ;

Adams, JM .

ONCOGENE, 2003, 22 (53) :8590-8607

[5] Structural insights into the degradation of Mcl-1 induced by BH3 domains [J].

Czabotar, Peter E. ;

Lee, Erinna F. ;

van Delft, Mark F. ;

Day, Catherine L. ;

Smith, Brian J. ;

Huang, David C. S. ;

Fairlie, W. Douglas ;

Hinds, Mark G. ;

Colman, Peter M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (15) :6217-6222

[6] Promoting apoptosis as a strategy for cancer drug discovery [J].

Fesik, SW .

NATURE REVIEWS CANCER, 2005, 5 (11) :876-885

[7] BH3-only proteins: orchestrating cell death [J].

Fletcher, J. I. ;

Huang, D. C. S. .

CELL DEATH AND DIFFERENTIATION, 2006, 13 (08) :1268-1271

[8] At the gates of death [J].

Green, DR .

CANCER CELL, 2006, 9 (05) :328-330

[9] Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia [J].

Konopleva, Marina ;

Contractor, Rooha ;

Tsao, Twee ;

Samudio, Ismael ;

Ruvalo, Peter P. ;

Kitada, Shinichi ;

Deng, Xingming ;

Zhai, Dayong ;

Shi, Yue-Xi ;

Sneed, Thomas ;

Verhaegen, Monique ;

Soengas, Maria ;

Ruvolo, Vivian R. ;

McQueen, Teresa ;

Schober, Wendy D. ;

Watt, Julie C. ;

Jiffar, Tilahun ;

Ling, Xiaoyang ;

Marini, Frank C. ;

Harris, David ;

Dietrich, Martin ;

Estrov, Zeev ;

McCubrey, James ;

May, W. Stratford ;

Reed, John C. ;

Andreeff, Michael .

CANCER CELL, 2006, 10 (05) :375-388

[10] A structural viral mimic of prosurvival Bcl-2: A pivotal role for sequestering proapoptotic Bax and Bak [J].

Kvansakul, Marc ;

van Delft, Mark F. ;

Lee, Erinna F. ;

Gulbis, Jacqueline M. ;

Fairlie, W. Douglas ;

Huang, David C. S. ;

Colman, Peter M. .

MOLECULAR CELL, 2007, 25 (06) :933-942

← 1 2 →