Biomimetic studies towards the C28-C40 polycyclic domain of the azaspiracids

被引：38

作者：

Aiguade, J ^{[1
]}

Hao, JL ^{[1
]}

Forsyth, CJ ^{[1
]}

机构：

[1] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(00)02156-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An acyclic intermediate representing a putative biomimetic precursor of the C28-C40 domain of the novel marine toxin azaspiracid was constructed convergently from C28-C34 and C35-C40 fragments. In studying the assembly of the C28-C34 dioxabicyclo[3.3.1]nonane system via an intramolecular hetero-conjugate addition upon a C34-C36 enone, a stereoselective C-Michael addition intervened to provide a highly substituted cyclohexane. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：817 / 820

页数：4

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