Stability of Novel Siderophore Cephalosporin S-649266 against Clinically Relevant Carbapenemases

被引：159

作者：

Ito-Horiyama, Tsukasa ^{[1
]}

Ishii, Yoshikazu ^{[2
]}

Ito, Akinobu ^{[1
]}

Sato, Takafumi ^{[1
]}

Nakamura, Rio ^{[1
]}

Fukuhara, Norio ^{[3
]}

Tsuji, Masakatsu ^{[1
]}

Yamano, Yoshinori ^{[1
]}

Yamaguchi, Keizo ^{[2
]}

Tateda, Kazuhiro ^{[2
]}

机构：

[1] Shionogi & Co Ltd, Discovery Res Lab Core Therapeut Areas, Osaka, Japan

[2] Toho Univ, Sch Med, Tokyo, Japan

[3] Shionogi & Co Ltd, Global Innovat Off, Osaka, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 07期

关键词：

D O I：

10.1128/AAC.03098-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To better understand the antibacterial activity of S-649266 against carbapenemase producers, its stability against clinically relevant carbapenemases was investigated. The catalytic efficiencies (k(cat)/K-m) of IMP-1, VIM-2, and L1 for S-649266 were 0.0048, 0.0050, and 0.024 mu M-1 s(-1), respectively, which were more than 260-fold lower than that for meropenem. Only slight hydrolysis of S-649266 against KPC-3 was observed. NDM-1 hydrolyzed meropenem 3-fold faster than S-649266 at 200 mu M.

引用

页码：4384 / 4386

页数：3

共 14 条

[1] THE STRUCTURE OF BETA-LACTAMASES [J].

AMBLER, RP .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1980, 289 (1036) :321-331

[2] CENTA as a chromogenic substrate for studying β-lactamases [J].

Bebrone, C ;

Moali, C ;

Mahy, F ;

Rival, S ;

Docquier, JD ;

Rossolini, GM ;

Fastrez, J ;

Pratt, RF ;

Frère, JM ;

Galleni, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (06) :1868-1871

[3]

Clinical and Laboratory Standards Institute, 2012, M07A9 CLSI

[4] On functional and structural heterogeneity of VIM-type metallo-β-lactamases [J].

Docquier, JD ;

Lamotte-Brasseur, J ;

Galleni, M ;

Amicosante, G ;

Frère, JM ;

Rossolini, GM .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 51 (02) :257-266

[5] OXA β-Lactamases [J].

Evans, Benjamin A. ;

Amyes, Sebastian G. B. .

CLINICAL MICROBIOLOGY REVIEWS, 2014, 27 (02) :241-263

[6] In vitro antimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria [J].

Ito, Akinobu ;

Kohira, Naoki ;

Bouchillon, Samuel K. ;

West, Joshua ;

Rittenhouse, Stephen ;

Sader, Helio S. ;

Rhomberg, Paul R. ;

Jones, Ronald N. ;

Yoshizawa, Hidenori ;

Nakamura, Rio ;

Tsuji, Masakatsu ;

Yamano, Yoshinori .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2016, 71 (03) :670-677

[7] In Vitro Antimicrobial Activity of a Siderophore Cephalosporin, S-649266, against Enterobacteriaceae Clinical Isolates, Including Carbapenem-Resistant Strains [J].

Kohira, Naoki ;

West, Joshua ;

Ito, Akinobu ;

Ito-Horiyama, Tsukasa ;

Nakamura, Rio ;

Sato, Takafumi ;

Rittenhouse, Stephen ;

Tsuji, Masakatsu ;

Yamano, Yoshinori .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 60 (02) :729-734

[8]

Nakamura RTS, 2014, 54 INT C ANT AG CHEM

[9] Carbapenemase-producing Enterobacteriaceae: Overview of a major public health challenge [J].

Nordmann, P. .

MEDECINE ET MALADIES INFECTIEUSES, 2014, 44 (02) :51-56

[10] TRANSFERRINS AND HEME-COMPOUNDS AS IRON SOURCES FOR PATHOGENIC BACTERIA [J].

OTTO, BR ;

VERWEIJVANVUGHT, AMJJ ;

MACLAREN, DM .

CRITICAL REVIEWS IN MICROBIOLOGY, 1992, 18 (03) :217-233

← 1 2 →