Neuroprotective effect of silymarin in 6-hydroxydopamine hemi-parkinsonian rat: Involvement of estrogen receptors and oxidative stress

被引：88

作者：

Baluchnejadmojarad, Tourandokht ^{[1
]}

Roghani, Mehrdad ^{[2
,3
]}

Mafakheri, Mehdi ^{[1
]}

机构：

[1] Iran Univ Med Sci, Sch Med, Dept Physiol, Tehran, Iran

[2] Shahed Univ, Sch Med, Dept Physiol, Tehran, Iran

[3] Shahed Univ, Med Plant Res Ctr, Tehran, Iran

来源：

NEUROSCIENCE LETTERS | 2010年 / 480卷 / 03期

关键词：

Silymarin; 6-Hydroxydopamine; Parkinson's disease; Estrogen receptor; Oxidative stress; MILK THISTLE; INDUCED NEUROTOXICITY; NEUROBLASTOMA-CELLS; SILYBUM-MARIANUM; DISEASE; BRAIN; MODEL; MECHANISMS; PROTECTION; SILIBININ;

D O I：

10.1016/j.neulet.2010.06.038

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study examined neuroprotective effect of silymarin (SM) in a model of Parkinson's disease (PD). Unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were pretreated i.p. with SM (100 and 200 mg/kg) 1 h before neurotoxin injection. Fulvestrant was used to evaluate the involvement of estrogen receptors. Net apomorphine-induced rotations and number of Nissl-stained neurons of substantia nigra pars compacta (SNC) were counted in addition to measurement of oxidative stress markers. SM administration only at a dose of 200 mg/kg attenuated the rotational behavior in 6-OHDA-lesioned rats and protected the neurons of SNC against its toxicity and fulvestrant partially attenuated this beneficial effect of SM. In addition, pretreatment with SM at a dose of 200 mg/kg significantly decreased the 6-OHDA-induced thiobarbituric acid reactive substances (TBARS) formation. SM exhibits a dose-dependent neuroprotective effect against 6-OHDA toxicity, partly through attenuating oxidative stress and via an estrogenic pathway. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：206 / 210

页数：5

共 36 条

[1] Neuroprotective Effect of Genistein in 6-Hydroxydopamine Hemi-parkinsonian Rat Model [J].