The neuroprotective effects of polyphenols, their role in innate immunity and the interplay with the microbiota

被引：37

作者：

Annunziata, Giuseppe ^{[1
]}

Sureda, Antoni ^{[2
,3
,4
]}

Orhan, Ilkay Erdogan ^{[5
]}

Battino, Maurizio ^{[6
,7
,8
]}

Arnone, Angela ^{[9
]}

Jimenez-Garcia, Manuel ^{[10
]}

Capo, Xavier ^{[2
,3
]}

Cabot, Joan ^{[11
]}

Sanadgol, Nima ^{[12
,13
]}

Giampieri, Francesca ^{[14
,15
]}

Tenore, Gian Carlo ^{[1
]}

Kashani, Hamid Reza Khayat ^{[16
]}

Silva, Ana Sanches ^{[17
,18
]}

Habtemariam, Solomon ^{[19
,20
]}

Nabavi, Seyed Fazel ^{[21
]}

Nabavi, Seyed Mohammad ^{[21
]}

机构：

[1] Univ Naples Federico II, Dept Pharm, NutraPharmaLabs, Via Domenico Montesano 49, I-80131 Naples, Italy

[2] Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain

[3] Univ Balearic Isl IUNICS, Hlth Res Inst Balearic Is IdISBa, Palma De Mallorca 07122, Spain

[4] Ist Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr, Madrid 28029, Spain

[5] Gazi Univ, Dept Pharmacognosy, Fac Pharm, TR-06330 Ankara, Turkey

[6] Univ Vigo Vigo Campus, Nutr & Food Sci Grp, Dept Analyt & Food Chem, CITACA,CACTI, Vigo, Spain

[7] Univ Politecn Marche, Dept Clin Sci, Ancona, Italy

[8] Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China

[9] Univ Naples Federico II, Med Sch Naples, Dipartimento Med Clin & Chirurg, Unit Endocrinol, Via Sergio Pansini 5, I-80131 Naples, Italy

[10] Univ Balearic Isl UIB, Dept Biol, Neurophysiol Lab, Ctra Valldemossa Km 7-5, E-07122 Palma De Mallorca, Spain

[11] Univ Balearic Isl UIB, Dept Biol, Ctra Valldemossa Km 7-5, E-07122 Palma De Mallorca, Spain

[12] Univ Zabol, Dept Biol, Fac Sci, Zabol, Iran

[13] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Biomol Sci, Ribeirao Preto, Brazil

[14] Polytech Univ Marche, Dept Odontostomatol & Specialized Clin Sci, Fac Med, Ancona, Italy

[15] King Abdulaziz Univ, Dept Biochem, Fac Sci, Jeddah, Saudi Arabia

[16] Imam Hossein Hosp, Madani St, Theran, Iran

[17] Natl Inst Agr & Vet Res INIAV, Rua Lagidos, P-4485655 Oporto, Portugal

[18] Univ Porto, Ctr Study Anim Sci CECA, ICETA, Oporto, Portugal

[19] Univ Greenwich, Pharmacognosy Res Labs, Cent Ave, Charham Maritime ME4 4TB, Kent, England

[20] Univ Greenwich, Herbal Anal Serv UK, Cent Ave, Charham Maritime ME4 4TB, Kent, England

[21] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran, Iran

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2021年 / 128卷

关键词：

neurodegeneration; aging-related cognitive decline; innate immunity; polyphenols; nutraceutical; INDUCED MEMORY IMPAIRMENT; ALZHEIMERS-DISEASE MODEL; GUT-BRAIN AXIS; MOUSE MODEL; OXIDATIVE STRESS; PARKINSONS-DISEASE; CEREBRAL-ISCHEMIA; COGNITIVE DECLINE; SIGNALING PATHWAY; INDUCED NEUROTOXICITY;

D O I：

10.1016/j.neubiorev.2021.07.004

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Neurodegenerative disorders, particularly in the elderly population, represent one of the most pressing social and health-care problems in the world. Besides the well-established role of both oxidative stress and inflammation, alterations of the immune response have been found to be closely linked to the development of neurodegenerative diseases. Interestingly, various scientific evidence reported that an altered gut microbiota composition may contribute to the development of neuroinflammatory disorders. This leads to the proposal of the concept of the gut-brain-immune axis. In this scenario, polyphenols play a pivotal role due to their ability to exert neuroprotective, immunomodulatory and microbiota-remodeling activities. In the present review, we summarized the available literature to provide a scientific evidence regarding this neuroprotective and immunomodulatory effects and the interaction with gut microbiota of polyphenols and, the main signaling pathways involved that can explain their potential therapeutic application in neurodegenerative diseases.

引用

页码：437 / 453

页数：17

共 278 条

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