The role of the adipocyte hormone adiponectin in cardiovascular disease

被引：102
作者：
Hug, C
Lodish, HF [1 ]
机构：
[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
[2] Childrens Hosp, Div Resp Dis, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Boston, MA 02115 USA
[4] MIT, Dept Biol, Cambridge, MA 02142 USA
来源：
CURRENT OPINION IN PHARMACOLOGY | 2005年 / 5卷 / 02期
关键词：
D O I：
10.1016/j.coph.2005.01.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Adiponectin, a novel hormone made by fat tissue, regulates energy metabolism and endothelial activation. Serum levels of adiponectin are reduced in conditions that are associated with an increased risk of cardiovascular disease, such as diabetes and the metabolic syndrome. Adiponectin trimers assemble into higher-order oligomers, which have different signaling properties. Adiponectin trimers and a C-terminal globular domain activate AMP-activated protein kinase, whereas hexamer and high-molecular weight isoforms activate nuclear factor-kappa B signaling pathways. Exogenous adiponectin corrects metabolic defects that are associated with insulin resistance, and might protect the endothelium from the progression of cardiovascular disease. Receptors for adiponectin have been described and might provide future therapeutic targets for the treatment of cardiovascular disease.
引用
收藏
页码：129 / 134
页数：6
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