Physiology of neuronal-glial networking

被引：102

作者：

Verkhratsky, Alexei ^{[1
,2
]}

机构：

[1] Univ Manchester, Fac Life Sci, Manchester, Lancs, England

[2] ASCR, Inst Expt Med, Prague, Czech Republic

来源：

NEUROCHEMISTRY INTERNATIONAL | 2010年 / 57卷 / 04期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

Glia; Astrocytes; Glutamate receptors; Purinoceptors; Neuronal-glial signalling; GLUTAMATE-RECEPTOR SUBUNITS; EXCITATORY AMINO-ACIDS; NITRIC-OXIDE RELEASE; GATED ION CHANNELS; CELLS IN-SITU; ENDOPLASMIC-RETICULUM; NMDA RECEPTORS; P2X(7) RECEPTORS; CALCIUM WAVES; INTRACELLULAR CALCIUM;

D O I：

10.1016/j.neuint.2010.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuronal-glial networks are the substrate for the brain function. Evolution of the nervous system resulted in the appearance of highly specialized neuronal web optimized for rapid information transfer. This neuronal web is embedded into glial syncytium, thereby creating sophisticated neuronal-glial circuitry were both types of neural cells are working in concert, ensuring amplification of brain computational power. In addition neuroglial cells are fundamental for control of brain homeostasis and they represent the intrinsic brain defence system, being thus intimately involved in pathogenesis of neurological diseases. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：332 / 343

页数：12

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