CART peptides are modulators of mesolimbic dopamine and psychostimulants

被引：75

作者：

Jaworski, JN ^{[1
]}

Vicentic, A ^{[1
]}

Hunter, RG ^{[1
]}

Kimmel, HL ^{[1
]}

Kuhar, MJ ^{[1
]}

机构：

[1] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA

来源：

LIFE SCIENCES | 2003年 / 73卷 / 06期

关键词：

CART peptides; dopamine; psychostimulants;

D O I：

10.1016/S0024-3205(03)00394-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

CART peptide produces behavioral effects when injected into the VTA or nucleus accumbens. In the VTA, the peptide behaves like an endogenous psychostimulant and produces increased locomotor activity and conditioned place preference. Since this is blocked by dopamine receptor blockers, it presumably involves release of dopamine. But in the nucleus accumbens, CART peptide reduces the locomotor-increasing effects of cocaine. This suggests that the peptide is an interesting target for medications development. (C) 2003 Elsevier Science Inc. All rights reserved.

引用

页码：741 / 747

页数：7

共 31 条

[1] CART: from gene to function [J].

Adams, LD ;

Gong, W ;

Vechia, SD ;

Hunter, RG ;

Kuhar, MJ .

BRAIN RESEARCH, 1999, 848 (1-2) :137-140

[2] Absence of cocaine- and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet [J].

Asnicar, MA ;

Smith, DP ;

Yang, DD ;

Heiman, ML ;

Fox, N ;

Chen, YF ;

Hsiung, HM ;

Köster, A .

ENDOCRINOLOGY, 2001, 142 (10) :4394-4400

[3]

Bannon AW, 2001, J PHARMACOL EXP THER, V299, P1021

[4]

Binder EB, 2001, CURRENT ISSUES IN THE PSYCHOPHARMACOLOGY OF SCHIZOPHRENIA, P349

[5] Cocaine- and amphetamine-regulated transcript peptide-(55-102) and thyrotropin releasing hormone inhibit hypothalamic dopamine release [J].

Brunetti, L ;

Orlando, G ;

Michelotto, B ;

Recinella, L ;

Vacca, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 409 (02) :103-107

[6]

Couceyro P, 1998, SYNAPSE, V30, P1, DOI 10.1002/(SICI)1098-2396(199809)30:1<1::AID-SYN1>3.0.CO

[7]

2-7

[8] CART peptides: Therapeutic potential in obesity and feeding disorders [J].

Couceyro, PR ;

Lambert, PD .

DRUG NEWS & PERSPECTIVES, 1999, 12 (03) :133-136

[9] Cocaine- and amphetamine-regulated transciript peptide projections in the ventral midbrain:: Colocalization with γ-aminobutyric acid, melanin-concentrating hormone, dynorphin, and synaptic interactions with dopamine neurons [J].

Dallvechia-Adams, S ;

Kuhar, MJ ;

Smith, Y .

JOURNAL OF COMPARATIVE NEUROLOGY, 2002, 448 (04) :360-372

[10] CART peptide-immunoreactive projection from the nucleus accumbens targets substantia nigra pars reticulata neurons in the rat [J].

Dallvechia-Adams, S ;

Smith, Y ;

Kuhar, MJ .

JOURNAL OF COMPARATIVE NEUROLOGY, 2001, 434 (01) :29-39

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